Professor Mark T. Nelson

Photograph of Mark T. Nelson

Professor of Cardiovascular Medicine

Cardiovascular Medicine
University of Manchester
Core Technology Facility (3rd floor)
46 Grafton Street
Manchester
M13 9NT
UK

Department of Pharmacology
University of Vermont
Given Building, Room B-303
89 Beaumont Avenue
Burlington VT 05405-0068
USA

Role

Professor of Cardiovascular Medicine, The University of Manchester

Professor and Chair of Pharmacology, Professor of Molecular Physiology and Biophysics, University of Vermont, Link to Homepage

Visiting Professor, Department of Oxford

Google Scholar Citation Index

Memberships of Committees and Professional Bodies

  • Vermont Academy of Science and Engineering
  • American Physiological Society
  • American Society for Biochemistry and Molecular Biology (ASBMB)
  • American Society for Pharmacology & Experimental Therapeutics (ASPET)
  • Biophysical Society
  • Council on Basic Sciences, American Heart Association
  • Society of General Physiologists
  • Society for Neuroscience
  • Associate of Medical School Pharmacology

Research

Membrane transport and ion channels. In particular, to apply molecular, physiological, biophysical and pharmacological approaches to understand the roles of ion channels and calcium signaling in the function and dysfunction of smooth muscle, with an emphasis on urinary bladder and neurovascular coupling.

Link to Google Scholar Citation Index

Methodological Knowledge

  • Electrophysiology (patch clamp/bilayer/microelectrode techniques)
  • In vitro contraction and pressurized artery measurements
  • High-speed confocal calcium imaging
  • Fluorescence microscopy
  • Transport measurements with radioisotope tracers
  • Immunohisto- and cytochemistry
  • In vivo urodynamic, blood pressure and local cerebral blood flow measurements in mice
  • State-of-the-art PCR techniques (standard PCR, RT-PCR, etc.)
  • Southern and Western blot

Teaching

  • Toxicology Pharm 272 (Spring 2007 - Present)
    Lectures on Animal Toxins: Reptiles. Approximately 30 undergraduate and graduate students. Lecture: 1.5 hours/year.
  • Medicinal Chemistry Pharm 328 (Spring 2007 - Present) Lectures on calcium channel inhibitors, approximately 10 undergraduate and graduate students. Lecture 2 hours/year.
  • Molecular and Cellular Pharmacology Pharm 290 (Spring 2007 - Present) Lecture on ryanodine receptors, 2 hours/year.
  • Cardiovascular Physiology (Fall 2006 - Present)
    Lectures on cardiovascular system function, disease, and pharmacological intervention. Topics include membrane structure and function, receptor/drug interactions, excitable membranes, muscle contraction, control by the autonomic and somatic nervous systems, cardiac cycle, and mechanics of vascular blood flow. Approximately 14 graduate students. Lecture: 10 hours/year.
  • Introductory to Pharmacology 201 (Fall 2007 - Present)
    Lectures on hyperlipidemia, gonadal hormones, thyroid, bone pharmacology, vitamins, adrenal hormones, diabetes. Approximately 14 undergraduate students. Lecture: 6 hours/year.
  • Graduate Course in Neurochemistry (Fall 2005 - Present)
    Lecture and Discussion Group: calcium as an intracellular messenger. 4 hour/semester.
  • College of Medicine Vermont Integrated Curriculum (Generations and NMGI) (2004-present)
    Lectures on hyperlipidemia, diabetes, adrenal and thyroid. 20 hours/year.
  • Medical Pharmacology 301 (Summer) (1986-present)
    Lectures on hyperlipidemia, gonadal hormones, thyroid, bone pharmacology, vitamins, adrenal hormones, diabetes. Approximately 35 medical students. Lecture and Conference: 12 hours/year.
  • Pharmacology for Physical Therapists, Pharmacology 190 (1986-2000)
    Spring lectures (5) on Hyperlipidemia, Steroids, and Cardiovascular drugs. Approximately 60 undergraduate students. Lecture 9 hours/ year.
  • Graduate Course in Molecular and Cellular Pharmacology, Pharmacology 290
    Lectures on ion channel and ion pump pharmacology and biophysics. Approximately 15 graduate students. Lecture 6 hours/year.
  • Graduate Course in Molecular and Cell Biology (1986-1998)
    Lectures on ion channels. 2 lectures (4 hours) per year to approximately 30 graduate students

Biography

6/96- Chair, Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT
7/95-5/96 Interim Chair, Department of Pharmacology, University of Vermont
5/93- Professor, Department of Molecular Physiology & Biophysics, University of Vermont (Secondary)
7/92- Professor, Department of Pharmacology, College of Medicine, University of Vermont
7/90-6/92 Associate Professor with Tenure, Department of Pharmacology, University of Vermont
6/86-6/90 Assistant Professor, Department of Pharmacology, University of Vermont
9/84-5/86 Assistant Professor, Department of Pharmacology, University of Miami School of Medicine, Miami, FL
11/82-8/84 Research Assistant Professor, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD. Sponsor: Professor B.K. Krueger
6/81-10/82 Research Fellow of the Alexander von Humboldt Stiftung, Fakultät für Biologie, Universität Konstanz, West Germany. Sponsor: Professor P. Läuger
4/80-5/81 Research Fellow of the American Heart Association, Dept. of Physiology, University of Maryland, Baltimore, MD. Sponsor: Professor M.P. Blaustein

Qualifications

1980 Ph.D., Neural Sciences Washington University, St. Louis, MO Advisor: Prof. M.P. Blaustein
1976 B.A., Mathematics & Biology with Honors Tufts University, Medford, MA
1973 Undergraduate studies Swarthmore College, Swarthmore, PA

Collaborators and affiliated staff

Adam Greenstein, British Heart Foundation Intermediate Clinical Research Fellow, Institute of Cardiovascular Sciences, University of Manchester

Publications

2013

  • Cipolla, M., Sweet, J., Gokina, N., White, S. & Nelson, M (2013). Mechanisms of enhanced basal tone of brain parenchymal arterioles during early postischemic reperfusion: role of ET-1-induced peroxynitrite generation. J Cereb Blood Flow Metab, eScholarID:201847 | PMID:23778163 | DOI:10.1038/jcbfm.2013.99
  • Dabertrand, F., Hannah, R., Pearson, J., Hill-Eubanks, D., Brayden, J. & Nelson, M (2013). Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles. J Cereb Blood Flow Metab, 33(4), 479-82. eScholarID:201846 | PMID:23385200 | DOI:10.1038/jcbfm.2013.9
  • Dabertrand, F., Nelson, M. & Brayden, J (2013). Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation. Microcirculation, 20(4), 307-16. eScholarID:201848 | PMID:23216877 | DOI:10.1111/micc.12027
  • Dunn, K., Hill-Eubanks, D., Liedtke, W. & Nelson, M (2013). TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. Proc Natl Acad Sci U S A, 110(15), 6157-62. eScholarID:201850 | PMID:23530219 | DOI:10.1073/pnas.1216514110
  • Koide, M., Bonev, A., Nelson, M. & Wellman, G (2013). Subarachnoid blood converts neurally evoked vasodilation to vasoconstriction in rat brain cortex. Acta Neurochir Suppl, 115, 167-71. eScholarID:201851 | PMID:22890664 | DOI:10.1007/978-3-7091-1192-5_32

2012

  • Dabertrand, F., Nelson, M. & Brayden, J (2012). Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels. Circ Res, 110(2), 285-94. eScholarID:201853 | PMID:22095728 | DOI:10.1161/CIRCRESAHA.111.258145
  • Joshi, S., Nelson, M. & Werner, M (2012). Amplified NO/cGMP-mediated relaxation and ryanodine receptor-to-BKCa channel signalling in corpus cavernosum smooth muscle from phospholamban knockout mice. Br J Pharmacol, 165(2), 455-66. eScholarID:201856 | PMID:21718308 | DOI:10.1111/j.1476-5381.2011.01569.x
  • Koide, M., Bonev, A., Nelson, M. & Wellman, G (2012). Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels. Proc Natl Acad Sci U S A, 109(21), E1387-95. eScholarID:201852 | PMID:22547803 | DOI:10.1073/pnas.1121359109
  • Lavoie B, Nausch B, Zane E, Leonard M, Balemba O, Bartoo A, Wilcox R, Nelson MT, Carey MC, Mawe G. (2012). Disruption of Gallbladder Smoth Muscle Function is an Early Feature in the Development of Cholesterol Gallstone Disease. Neurogastroenterology and Motility, 10.111/j.1365-2982(2012.01935), 313-329. eScholarID:201866
  • Nausch, L., Bonev, A., Heppner, T., Tallini, Y., Kotlikoff, M. & Nelson, M (2012). Sympathetic nerve stimulation induces local endothelial Ca2+ signals to oppose vasoconstriction of mouse mesenteric arteries. Am J Physiol Heart Circ Physiol, 302(3), H594-602. eScholarID:201855 | PMID:22140050 | DOI:10.1152/ajpheart.00773.2011
  • Sonkusare SK, Bonev AD, Ledoux J, Liedtke W, Kotlikoff MI, Heppner TJ, Hill-Eubanks DC, Nelson MT. (2012). Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science, 336(6081), 5. eScholarID:176485 | DOI:10.1126/science.1216283
  • Sonkusare, S., Bonev, A., Ledoux, J., Liedtke, W., Kotlikoff, M., Heppner, T., Hill-Eubanks, D. & Nelson, M (2012). Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science, 336(6081), 597-601. eScholarID:201854 | PMID:22556255 | DOI:10.1126/science.1216283

2011

  • Hannah, R., Dunn, K., Bonev, A. & Nelson, M (2011). Endothelial SK(Ca) and IK(Ca) channels regulate brain parenchymal arteriolar diameter and cortical cerebral blood flow. J Cereb Blood Flow Metab, 31(5), 1175-86. eScholarID:201860 | PMID:21179072 | DOI:10.1038/jcbfm.2010.214
  • Hill-Eubanks, D., Werner, M., Heppner, T. & Nelson, M (2011). Calcium signaling in smooth muscle. Cold Spring Harb Perspect Biol, 3(9), a004549. eScholarID:201857 | PMID:21709182 | DOI:10.1101/cshperspect.a004549
  • Longden, T., Dunn, K., Draheim, H., Nelson, M., Weston, A. & Edwards, G (2011). Intermediate-conductance calcium-activated potassium channels participate in neurovascular coupling. Br J Pharmacol, 164(3), 922-33. eScholarID:201858 | PMID:21506954 | DOI:10.1111/j.1476-5381.2011.01447.x
  • Nystoriak, M., O'Connor, K., Sonkusare, S., Brayden, J., Nelson, M. & Wellman, G (2011). Fundamental increase in pressure-dependent constriction of brain parenchymal arterioles from subarachnoid hemorrhage model rats due to membrane depolarization. Am J Physiol Heart Circ Physiol, 300(3), H803-12. eScholarID:201859 | PMID:21148767 | DOI:10.1152/ajpheart.00760.2010

2010

  • Girouard H, Bonev AD, Hannah RM, Meredith A, Aldrich RW, Nelson MT. (2010). Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction. Proc Natl Acad Sci U S A, 107(8), 3811-3816. eScholarID:107517 | DOI:10.1073/pnas.0914722107
  • Girouard, H., Bonev, A., Hannah, R., Meredith, A., Aldrich, R. & Nelson, M (2010). Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction. Proc Natl Acad Sci U S A, 107(8), 3811-6. eScholarID:133795 | PMID:20133576 | DOI:10.1073/pnas.0914722107
  • Layne JJ, Nausch B, Olesen SP, Nelson MT. (2010). BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am J Physiol Regul Integr Comp Physiol, 298(2), 378-384. eScholarID:107513 | DOI:10.1152/ajpregu.00458.2009
  • Lu, C., Diehl, S., Noubade, R., Ledoux, J., Nelson, M., Spach, K., Zachary, J., Blankenhorn, E. & Teuscher, C (2010). Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis. Proc Natl Acad Sci U S A, 107(44), 18967-72. eScholarID:133794 | PMID:20956310 | DOI:10.1073/pnas.1008816107

2009

  • Heppner TJ, Werner ME, Nausch B, Vial C, Evans RJ, Nelson MT. (2009). Nerve-evoked purinergic signaling suppresses action potentials, Ca2+ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle. JPhysiology, eScholarID:53769
  • Straub SV, Girouard H, Doetsch PE, Hannah RM, Wilkerson MK, Nelson MT. (2009). Regulation of intracerebral arteriolar tone by Kv channels: Effects of glucose and PKC. American Journal of Physiology: Cell Physiology, eScholarID:1d20813 | DOI:10.1152/ajpcell.00148.2009

2008

  • Brayden, J., Earley, S., Nelson, M. & Reading, S (2008). Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow. Clin Exp Pharmacol Physiol, 35(9), 1116-20. eScholarID:133801 | PMID:18215190 | DOI:10.1111/j.1440-1681.2007.04855.x
  • Brown, S, Bentcheva-Petkova, L, Liu, L, Hristov, K, Chen, M, Kellett, W, Meredith, A, Aldrich, R, Nelson, MT, Petkov, G. (2008). Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel. American Journal of Physiology - Renal Physiology, 295( 4), F1149-57. eScholarID:1d20815 | DOI:10.1152/ajprenal.00440.2007
  • Layne J, Werner ME, Hill-Eubanks D, Nelson MT. (2008). NFATc3 Regulates BK Channel Function in Murine Urinary Bladder Smooth Muscle. American Journal of Physiology: Cell Physiology, 295, C611-C623. eScholarID:1d28220 | DOI:10.1152/ajpcell.00435.2007
  • Ledoux J, Bonev A, Nelson MT. (2008). Ca2+-activated K+ channels in murine endothelial cells: block by intracellular calcium and magnesium. J Gen Physiol, 131( 2), 125-35. eScholarID:1d20818 | DOI:10.1085/jgp.200709875
  • Ledoux J, Taylor M, Bonev A, Hannah R, Solodushko V, Shui B, Tallini Y, Kotlikoff M, Nelson MT. (2008). Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections. Proc Natl Acad Sci U S A, 105( 28), 9627-32. eScholarID:1d20814 | DOI:10.1073/pnas.0801963105
  • Ledoux, J., Taylor, M., Bonev, A., Hannah, R., Solodushko, V., Shui, B., Tallini, Y., Kotlikoff, M. & Nelson, M (2008). Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections. Proceedings of the National Academy of Sciences of the United States of America, 105(28), 9627. eScholarID:133796 | PMID:18621682 | DOI:10.1073/pnas.0801963105
  • Michael, S, Surks, H, Wang, Y, Zhu, Y, Blanton, R, Jamnongjit, M, Aronovitz, M, Baur, W, Ohtani, K, Wilkerson, M, Bonev, A, Nelson, MT, Karas, R, Mendelsohn, M. (2008). High blood pressure arising from a defect in vascular function. Proc Natl Acad Sci U S A, 105( 18), 6702-7. eScholarID:1d20816 | DOI:10.1073/pnas.0802128105
  • Michael, S., Surks, H., Wang, Y., Zhu, Y., Blanton, R., Jamnongjit, M., Aronovitz, M., Baur, W., Ohtani, K., Wilkerson, M., Bonev, A., Nelson, M., Karas, R. & Mendelsohn, M (2008). High blood pressure arising from a defect in vascular function. Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6702. eScholarID:133797 | PMID:18448676 | DOI:10.1073/pnas.0802128105
  • Nausch L, Ledoux J, Bonev A, Nelson MT, Dostmann W. (2008). Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors. Proc Natl Acad Sci U S A, 105( 1), 365-70. eScholarID:1d20819 | DOI:10.1073/pnas.0710387105
  • Nausch, L.W.M., Ledoux, J., Bonev, A.D., Nelson, M.T., and Dostmann, W.R. (2008). Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors. Proceedings of the National Academy of Sciences of the United States of America, 105(1), 365-370. eScholarID:133800 | DOI:10.1073/pnas.0710387105
  • Thorneloe K, Knorn A, Doetsch P, Lashinger E, Liu A, Bond C, Adelman J, Nelson MT. (2008). Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 294( 5), R1737-43. eScholarID:1d20817 | DOI:10.1152/ajpregu.00840.2006
  • Werner ME, Meredith AL, Aldrich RW, Nelson MT. (2008). Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 295, R181-R188. eScholarID:1d17316 | DOI:10.1152/ajpregu.00173.2008

2007

  • Filosa JA, Nelson MT, Gonzalez Bosc LV. (2007). Activity-Dependent NFATc3 Nuclear Accumulation in Pericytes from Cortical Parenchymal Microvessel. American Journal of Physiology: Cell Physiology, eScholarID:1d16325 | DOI:10.1152/ajpcell.00435.2007
  • Lavoie B, Balemba O, Nelson MT, Ward S, Mawe G. (2007). Morphological and physiological evidence for interstitial cell of Cajal-like cells in the guinea pig gallbladder. Journal of Physiology, 579( Pt 2), 487-501. eScholarID:1d16344
  • Mandalà M, Heppner T, Bonev A, Nelson MT. (2007). Effect of endogenous and exogenous nitric oxide on calcium sparks as targets for vasodilation in rat cerebral artery. Nitric Oxide, 16( 1), 104-9. eScholarID:1d16345
  • Morita H, Honda A, Inoue R, Ito Y, Abe K, Nelson MT, Brayden J. (2007). Membrane stretch-induced activation of a TRPM4-like nonselective cation channel in cerebral artery myocytes. Journal of Pharmacological Sciences, 103( 4), 417-26. eScholarID:1d16327
  • Straub S, Nelson MT. (2007). Astrocytic calcium signaling: the information currency coupling neuronal activity to the cerebral microcirculation. Trends in Cardiovascular Medicine, 17( 6), 183-90. eScholarID:1d16326
  • Werner ME, Knorn A-M, Meredith AL, Aldrich RW, Nelson MT. (2007). Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: Modulation by BK channels. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 292, R616-R624. eScholarID:1d27502 | DOI:10.1152/ajpregu.00036.2006

2006

  • Balemba O, Heppner T, Bonev A, Nelson MT, Mawe G. (2006). Calcium waves in intact guinea pig gallbladder smooth muscle cells. American Journal of Physiology-Gastrointestinal Liver Physiology, 291( 4), G717-27. eScholarID:1d16349
  • Balemba O, Salter M, Heppner T, Bonev A, Nelson MT, Mawe G. (2006). Spontaneous electrical rhythmicity and the role of the sarcoplasmic reticulum in the excitability of guinea pig gallbladder smooth muscle cells. American Journal Physiology-Gastrointestinal and Liver Physiology, 290( 4), G655-64. eScholarID:1d16352
  • Braas K, May V, Zvara P, Nausch B, Kliment J, Dunleavy J, Nelson MT, Vizzard M. (2006). Role for pituitary adenylate cyclase activating polypeptide in cystitis-induced plasticity of micturition reflexes. American Journal of Physiology-Gastrointestinal and Liver Physiology, 290( 4), R951-62. eScholarID:1d16351
  • Earley S, Nelson MT. (2006). Central role of Ca2+-dependent regulation of vascular tone in vivo. Journal of Applied Physiology, 101( 1), 10-1. eScholarID:1d16348
  • Filosa JA, Bonev AD, Straub SV, Meredith AL, Wilkerson MK, Aldrich RW, Nelson MT. (2006). Local potassium signaling couples neuronal activity to vasodilation in the brain. Nature Neuroscience, 9(11), 1397-1403. eScholarID:1d27551 | DOI:10.1038/nn1779
  • Ledoux J, Werner ME, Brayden J, Nelson MT. (2006). Calcium-activated potassium channels and the regulation of vascular tone. Physiology (Review), 21, 69-78. eScholarID:1d16350 | DOI:10.1152/physiol.00040.2005
  • Straub S, Nelson MT. (2006). A spoonful of sugar helps the KV channel activity go down. Journal of Physiology, 575( Pt 3), eScholarID:1d16346
  • Straub S, Nelson MT. (2006). Molecular coding of Kv1 channels to oppose myogenic constriction. Circulation Research, 99( 1), 13-4. eScholarID:1d16347
  • Straub SV, Bonev AD, Wilkerson MK, Nelson MT. (2006). Dynamic Inositol Trisphosphate-mediated Calcium Signals within Astrocytic Endfeet Underlie Vasodilation of Cerebral Arterioles. Journal of General Physiology, 128(6), 659-669. eScholarID:1d27552 | DOI:10.1085/jgp.200609650
  • Wilkerson M, Heppner T, Bonev A, Nelson MT. (2006). Inositol trisphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology-Heart and Circulatory Physiology, 290( 1), H240-7. eScholarID:1d16354

2005

  • Earley S, Heppner T, Nelson MT, Brayden J. (2005). TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. Circulation Research, 97( 12), 1270-9. eScholarID:1d16353
  • Gonzalez Bosc L, Layne J, Nelson MT, Hill-Eubanks D. (2005). Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer. Journal of Biological Chemistry, 280( 28), 26113-20. eScholarID:1d16362
  • Heppner T, Bonev A, Eckman D, Gomez M, Petkov G, Nelson MT. (2005). Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. Pharmacology, 73( 1), 15-22. eScholarID:1d16364
  • Heppner T, Bonev A, Nelson MT. (2005). Elementary purinergic Ca2+ transients evoked by nerve stimulation in rat urinary bladder smooth muscle. Journal of Physiology, 564( Pt 1), 201-12. eScholarID:1d16358
  • Herrera G, Etherton B, Nausch B, Nelson MT. (2005). Negative feedback regulation of nerve-mediated contractions by KCa channels in mouse urinary bladder smooth muscle. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 289( 2), R402-R409. eScholarID:1d16361
  • Mokelke E, Dietz N, Eckman D, Nelson MT, Sturek M. (2005). Diabetic dyslipidemia and exercise affect coronary tone and differential regulation of conduit and microvessel K+ current. American Journal of Physiology-Heart and Circulatory Physiology, 288( 3), H1233-41. eScholarID:1d16357
  • Petkov G, Balemba O, Nelson MT, Mawe G. (2005). Identification of a spontaneously active, Na+-permeable channel in guinea pig gallbladder smooth muscle. American Journal of Physiology-Gastrointestinal and Liver Physiology, 289( 3), G501-7. eScholarID:1d16355
  • Petkov G, Nelson MT. (2005). Differential regulation of Ca2+-activated K+ channels by beta-adrenoceptors in guinea pig urinary bladder smooth muscle. American Journal of Physiology-Cell Physiology, 288( 6), C1255-63. eScholarID:1d16495
  • Thorneloe K, Meredith A, Knorn A, Aldrich R, Nelson MT. (2005). Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. American Journal of Physiology-Renal Physiology, 289( 3), F604-10. eScholarID:1d16360
  • Thorneloe K, Nelson MT. (2005). Ion channels in smooth muscle: regulators of intracellular calcium and contractility. Canadian Journal of Physiology and Pharmacology (Review), 83( 3), 215-42. eScholarID:1d16356
  • Werner ME, Zvara P, Meredith AL, Aldrich RW, Nelson MT. (2005). Erectile dysfunction in mice lacking in large conductance calcium-activated (BK) channel. Journal of Physiology, 567(Pt 2), 545-56. eScholarID:1d27503 | DOI:10.1113/jphysiol.2005.093823

2004

  • Etherton B, Heppner T, Cumming J, Nelson MT. (2004). Opposing effects of aluminum on inward-rectifier potassium currents in bean root-tip protoplasts. Journal of Membrane Biology, 198( 1), 15-22. eScholarID:1d16365
  • Filosa J, Bonev A, Nelson MT. (2004). Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. Circulation Research, 95( 10), e73-81. eScholarID:1d16363
  • Gonzalez Bosc L, Wilkerson M, Bradley K, Eckman D, Hill-Eubanks D, Nelson MT. (2004). Intraluminal pressure is a stimulus for NFATc3 nuclear accumulation: role of calcium, endothelium-derived nitric oxide, and cGMP-dependent protein kinase. Journal of Biological Chemistry, 279( 11), 10702-9. eScholarID:1d16369
  • Meredith AL, Thorneloe KS, Werner ME, Nelson MT, Aldrich RW. (2004). Overactive bladder and incontinence in the absence of the BK large conductance Ca2+ -activated K+ channel. Journal of Biological Chemistry, 279, 36746-52. eScholarID:1d16095 | DOI:10.1074/jbc.M405621200
  • Nelson MT, Bonev A. (2004). The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension. Journal of Clinical Investigation, 113( 7), 955-7. eScholarID:1d16367
  • Thorneloe K, Nelson MT. (2004). Properties of a tonically active, sodium-permeable current in mouse urinary bladder smooth muscle. American Journal of Physiology-Cell Physiology, 286( 6), C1246-57. eScholarID:1d16368

2003

  • Amberg G, Bonev A, Rossow C, Nelson MT, Santana L. (2003). Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension. Journal of Clinical Investigation, 112( 5), 717-24. eScholarID:1d16372
  • Gomez M, Bosc L, Stevenson A, Wilkerson M, Hill-Eubanks D, Nelson MT. (2003). Constitutively elevated nuclear export activity opposes Ca2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1. Journal of Biological Chemistry, 278( 47), 46847-53. eScholarID:1d16371
  • Heppner T, Herrera G, Bonev A, Hill-Eubanks D, Nelson MT. (2003). Ca2+ sparks and K(Ca) channels: novel mechanisms to relax urinary bladder smooth muscle. Advances in Experimental Medicine and Biology, 539( Pt A), 347-57. eScholarID:1d16366
  • Herrera G, Pozo M, Zvara P, Petkov G, Bond C, Adelman J, Nelson MT. (2003). Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel. Journal of Physiology, 551( Pt 3), 893-903. eScholarID:1d16374
  • Hill-Eubanks D, Gomez M, Stevenson A, Nelson MT. (2003). NFAT regulation in smooth muscle. Trends in Cardiovascular Medicine, 13( 2), 56-62. eScholarID:1d16376
  • Li P, Lee H, Nelson MT, Meininger G, Van Breemen C. (2003). Novel Ca2+ signalling mechanisms in vascular myocytes: symposium overview. Acta Physiologica Scandinavia, 179( 4), 339-52. eScholarID:1d16370
  • Parr E, Pozo M, Horowitz B, Nelson MT, Mawe G. (2003). ERG K+ channels modulate the electrical and contractile activities of gallbladder smooth muscle. American Journal of Physiology-Gastrointestinal and Liver Physiology, 284( 3), G392-8. eScholarID:1d16377
  • Taylor MS, Bonev AD, Gross TP, Eckman DM, Brayden JE, Bond CT, Adelman JP, Nelson MT. (2003). Altered expression of small conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure. Circulation Research, 93(2), 124-131. eScholarID:1d27498 | DOI:10.1161/01.RES.0000081980.63146.69
  • Thorneloe K, Nelson MT. (2003). Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. Journal of Physiology, 549( Pt 1), 65-74. eScholarID:1d16375
  • Wellman G, Nelson MT. (2003). Signaling between SR and plasmalemma in smooth muscle: sparks and the activation of Ca2+-sensitive ion channels. Cell Calcium (Review), 34( 3), 211-29. eScholarID:1d16373

2002

  • Gomez MF, Stevenson AS, Bonev AD, Hill-Eubanks DC, Nelson MT. (2002). Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle. Journal of Biological Chemistry, 277(40), 37756-64. eScholarID:1d27500 | DOI:10.1074/jbc.M203596200
  • Heppner TJ, Bonev AD, Santana LF, Nelson MT. (2002). Alkaline pH shifts Ca2+ sparks to Ca2+ waves in smooth muscle cells of pressurized cerebral arteries. American Journal of Physiology - Heart and Circulatory Physiology, H2169-H2176, eScholarID:1d27499
  • Herrera G, Nelson MT. (2002). Differential regulation of SK and BK channels by Ca(2+) signals from Ca(2+) channels and ryanodine receptors in guinea-pig urinary bladder myocytes. Journal of Physiology, 541( Pt 2), 483-92. eScholarID:1d16359
  • Herrera G, Nelson MT. (2002). Sarcoplasmic reticulum and membrane currents. Novartis Foundation Symposium, 246, 189-203; discussion. eScholarID:1d16379 | DOI:10.1002/0470853050.ch14
  • Nelson MT, Herrera G. (2002). Molecular physiology: protecting the heart. Nature, 416( 6878), 273-4. eScholarID:1d16380
  • Pozo M, Pérez G, Nelson MT, Mawe G. (2002). Ca(2+) sparks and BK currents in gallbladder myocytes: role in CCK-induced response. American Journal of Physiology-Gastrointestinal and Liver Physiology, 282( 1), G165-74. eScholarID:1d16381
  • Santana L, Chase E, Votaw V, Nelson MT, Greven R. (2002). Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes. Journal of Physiology, 544( Pt 1), 57-69. eScholarID:1d16378
  • Wellman GC, Nathan DJ, Saundry CM, Perez G, Penar PL, Tranmer BI, Nelson MT. (2002). Ca2+ sparks and their function in human cerebral arteries. Stroke, 33(3), 802-8. eScholarID:1d27501
  • Welsh DG, Morielli AD, Nelson MT. (2002). Transient receptor potential channels regulate myogenic tone of resistance arteries. Circulation Research, 90 (3), 248-250. eScholarID:1d27706

2001

  • Eckman D, Nelson MT. (2001). Potassium ions as vasodilators: role of inward rectifier potassium channels. Circulation Research, 88( 2), 132-3. eScholarID:1d16389
  • Herrera G, Heppner T, Nelson MT. (2001). Voltage dependence of the coupling of Ca(2+) sparks to BK(Ca) channels in urinary bladder smooth muscle. American Journal of Physiology-Cell Physiology, 280( 3), C481-90. eScholarID:1d16388
  • Pérez G, Bonev A, Nelson MT. (2001). Micromolar Ca(2+) from sparks activates Ca(2+)-sensitive K(+) channels in rat cerebral artery smooth muscle. American Journal of Physiology-Cell Physiology, 281( 6), C1769-75. eScholarID:1d16383
  • Petkov G, Bonev A, Heppner T, Brenner R, Aldrich R, Nelson MT. (2001). Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle. Journal of Physiology, 537( Pt 2), 443-52. eScholarID:1d16382
  • Petkov G, Heppner T, Bonev A, Herrera G, Nelson MT. (2001). Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 280( 5), R1427-33. eScholarID:1d16386
  • Schubert R, Nelson MT. (2001). Protein kinases: tuners of the BKCa channel in smooth muscle. Trends in Pharmacological Sciences, 22( 10), 505-12. eScholarID:1d16384
  • Stevenson A, Cartin L, Wellman T, Dick M, Nelson MT, Lounsbury K. (2001). Membrane depolarization mediates phosphorylation and nuclear translocation of CREB in vascular smooth muscle cells. Experimental Cell Research, 263( 1), 118-30. eScholarID:1d16494
  • Stevenson A, Gomez M, Hill-Eubanks D, Nelson MT. (2001). NFAT4 movement in native smooth muscle. A role for differential Ca(2+) signaling. Journal of Biological Chemistry, 276( 18), 15018-24. eScholarID:1d16387
  • Wellman G, Santana L, Bonev A, Nelson MT. (2001). Role of phospholamban in the modulation of arterial Ca(2+) sparks and Ca(2+)-activated K(+) channels by cAMP. American Journal of Physiology-Cell Physiology, 281( 3), C1029-37. eScholarID:1d16385
  • Wellman GC, Cartin L, Eckman DM, Stevenson AS, Saundry CM, Lederer WJ, Nelson MT. (2001). Membrane depolarization, elevated Ca(2+) entry, and gene expression in cerebral arteries of hypertensive rats. American Journal of Physiology-Heart & Circulatory Physiology, 281(6), H2559-67. eScholarID:1d14833

2000

  • Bayguinov O, Hagen B, Bonev A, Nelson MT, Sanders K. (2000). Intracellular calcium events activated by ATP in murine colonic myocytes. American Journal of Physiology-Cell Physiology, 279( 1), C126-35. eScholarID:1d16397
  • Brenner R, Peréz G, Bonev A, Eckman D, Kosek J, Wiler S, Patterson A, Nelson MT, Aldrich R. (2000). Vasoregulation by the beta1 subunit of the calcium-activated potassium channel. Nature, 407( 6806), 870-6. eScholarID:1d16390
  • Cartin L, Lounsbury K, Nelson MT. (2000). Coupling of Ca(2+) to CREB activation and gene expression in intact cerebral arteries from mouse : roles of ryanodine receptors and voltage-dependent Ca(2+) channels. Circulation Research, 86( 7), 760-7. eScholarID:1d16402
  • Firth T, Mawe G, Nelson MT. (2000). Pharmacology and modulation of K(ATP) channels by protein kinase C and phosphatases in gallbladder smooth muscle. American Journal of Physiology-Cell Physiology, 278( 5), C1031-7. eScholarID:1d16399
  • Gollasch M, Löhn M, Fürstenau M, Nelson MT, Luft F, Haller H. (2000). Ca2+ channels, Ca2+ sparks, and regulation of arterial smooth muscle function. Zeitschrift fur Kardiologie, 89 Suppl 2, 15-9. eScholarID:1d16400
  • Gollasch M, Löhn M, Furstenau M, Nelson MT, Luft F, Haller H. (2000). Ca2+ channels, 'quantized' Ca2+ release, and differentiation of myocytes in the cardiovascular system. Journal of Hypertension, 18( 8), 989-98. eScholarID:1d16394
  • Hemming J, Guarraci F, Firth T, Jennings L, Nelson MT, Mawe G. (2000). Actions of histamine on muscle and ganglia of the guinea pig gallbladder. American Journal of Physiology-Gastrointestinal and Liver Physiology, 279( 3), G622-30. eScholarID:1d16393
  • Herrera G, Heppner T, Nelson MT. (2000). Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 279( 1), R60-8. eScholarID:1d16398
  • Jaggar J, Nelson MT. (2000). Differential regulation of Ca(2+) sparks and Ca(2+) waves by UTP in rat cerebral artery smooth muscle cells. American Journal of Physiology-Cell Physiology, 279( 5), C1528-39. eScholarID:1d16391
  • Jaggar J, Porter V, Lederer W, Nelson MT. (2000). Calcium sparks in smooth muscle. American Journal of Physiology-Cell Physiology, 278( 2), C235-56. eScholarID:1d16401
  • Welsh D, Nelson MT, Eckman D, Brayden J. (2000). Swelling-activated cation channels mediate depolarization of rat cerebrovascular smooth muscle by hyposmolarity and intravascular pressure. Journal of Physiology, 527 Pt 1, 139-48. eScholarID:1d16395
  • Welsh D, Nelson MT. (2000). A case for myoendothelial gap junctions. Circulation Research, 87( 6), 427-8. eScholarID:1d16392
  • Zaritsky J, Eckman D, Wellman G, Nelson MT, Schwarz T. (2000). Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation. Circulation Research, 87( 2), 160-6. eScholarID:1d16396

1999

  • Bradley K, Jaggar J, Bonev A, Heppner T, Flynn E, Nelson MT, Horowitz B. (1999). Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells. Journal of Physiology, 515 ( Pt 3), 639-51. eScholarID:1d16407
  • Gokina N, Knot H, Nelson MT, Osol G. (1999). Increased Ca2+ sensitivity as a key mechanism of PKC-induced constriction in pressurized cerebral arteries. American Journal of Physiology-Heart and Circulatory Physiology, 277( 3 Pt 2), H1178-88. eScholarID:1d16404
  • Jennings L, Xu Q, Firth T, Nelson MT, Mawe G. (1999). Cholesterol inhibits spontaneous action potentials and calcium currents in guinea pig gallbladder smooth muscle. American Journal of Physiology-Gastrointestinal and Liver Physiology, 277( 5 Pt 1), G1017-26. eScholarID:1d16403
  • Knot H, Lounsbury K, Brayden J, Nelson MT. (1999). Gender differences in coronary artery diameter reflect changes in both endothelial Ca2+ and ecNOS activity. American Journal of Physiology-Heart and Circulatory Physiology, 276( 3 Pt 2), H961-9. eScholarID:1d16406
  • Kotlikoff M, Herrera G, Nelson MT. (1999). Calcium permeant ion channels in smooth muscle. Reviews in Physiology, Biochemistry, and Pharmacology, 134, 147-99. eScholarID:1d16405
  • Pérez G, Bonev A, Patlak J, Nelson MT. (1999). Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries. Journal of General Physiology, 113( 2), 229-38. eScholarID:1d16408
  • Vichi P, Whelchel A, Knot H, Nelson MT, Kolch W, Posada J. (1999). Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and Raf activation. American Journal of Respiratory Cell & Molecular Biology, 20( 1), 99-105. eScholarID:1d16496

1998

  • Gollasch M, Wellman G, Knot H, Jaggar J, Damon D, Bonev A, Nelson MT. (1998). Ontogeny of local sarcoplasmic reticulum Ca2+ signals in cerebral arteries: Ca2+ sparks as elementary physiological events. Circulation Research, 83( 11), 1104-14. eScholarID:1d16410
  • Jaggar J, Mawe G, Nelson MT. (1998). Voltage-dependent K+ currents in smooth muscle cells from mouse gallbladder. American Journal of Physiology-Gastrointestinal and Liver Physiology, 274( 4 Pt 1), G687-93. eScholarID:1d16416
  • Jaggar J, Stevenson A, Nelson MT. (1998). Voltage dependence of Ca2+ sparks in intact cerebral arteries. American Journal of Physiology-Cell Physiology, 274( 6 Pt 1), C1755-61. eScholarID:1d16414
  • Jaggar, J, Wellman, G, Heppner, T, Porter, V, Perez, G, Gollasch, M, Kleppisch, T, Rubart, M, Stevenson, A, Lederer, W, Knot, H, Bonev, A, Nelson, MT. (1998). Ca2+ channels, ryanodine receptors and Ca(2+)-activated K+ channels: a functional unit for regulating arterial tone. Acta Physiologica Scandinavica, 164( 4), 577-87. eScholarID:1d16409
  • Knot H, Nelson MT. (1998). Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure. Journal of Physiology, 508 ( Pt 1), 199-209. eScholarID:1d16412
  • Knot H, Standen N, Nelson MT. (1998). Ryanodine receptors regulate arterial diameter and wall [Ca2+] in cerebral arteries of rat via Ca2+-dependent K+ channels. Journal of Physiology, 508 ( Pt 1), 211-21. eScholarID:1d16411
  • Nelson MT. (1998). Bayliss, myogenic tone and volume-regulated chloride channels in arterial smooth muscle. Journal of Physiology, 507 ( Pt 3), eScholarID:1d16415
  • Porter V, Bonev A, Knot H, Heppner T, Stevenson A, Kleppisch T, Lederer W, Nelson MT. (1998). Frequency modulation of Ca2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides. American Journal of Physiology-Cell Physiology, 274( 5 Pt 1), C1346-55. eScholarID:1d16413

1997

  • Bonev A, Jaggar J, Rubart M, Nelson MT. (1997). Activators of protein kinase C decrease Ca2+ spark frequency in smooth muscle cells from cerebral arteries. American Journal of Physiology-Cell Physiology, 273( 6 Pt 1), C2090-5. eScholarID:1d16417
  • Gollasch M, Nelson MT. (1997). Voltage-dependent Ca2+ channels in arterial smooth muscle cells. Kidney & Blood Pressure Research, 20( 6), 355-71. eScholarID:1d16422
  • Heppner T, Bonev A, Nelson MT. (1997). Ca(2+)-activated K+ channels regulate action potential repolarization in urinary bladder smooth muscle. American Journal of Physiology-Cell Physiology, 273( 1 Pt 1), C110-7. eScholarID:1d16421
  • Nelson MT, Conway M, Knot H, Brayden J. (1997). Chloride channel blockers inhibit myogenic tone in rat cerebral arteries. Journal of Physiology, 502 ( Pt 2), 259-64. eScholarID:1d16420
  • Quayle J, Nelson MT, Standen N. (1997). ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiological Reviews, 77( 4), 1165-232. eScholarID:1d16419
  • Zimmermann P, Knot H, Stevenson A, Nelson MT. (1997). Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats. Circulation Research, 81( 6), 996-1004. eScholarID:1d16418

1996

  • Aquilla E, Whelchel A, Knot H, Nelson MT, Posada J. (1996). Activation of multiple mitogen-activated protein kinase signal transduction pathways by the endothelin B receptor requires the cytoplasmic tail. Journal of Biological Chemistry, 271( 49), 31572-9. eScholarID:1d16497
  • Bonev A, Nelson MT. (1996). Vasoconstrictors inhibit ATP-sensitive K+ channels in arterial smooth muscle through protein kinase C. Journal of General Physiology, 108( 4), 315-23. eScholarID:1d16425
  • Heppner T, Bonev A, Li J, Kau S, Nelson MT. (1996). Zeneca ZD6169 activates ATP-sensitive K+ channels in the urinary bladder of the guinea pig. Pharmacology, 53( 3), 170-9. eScholarID:1d16426
  • Kleppisch T, Winter B, Nelson MT. (1996). ATP-sensitive potassium channels in cultured arterial segments. American Journal of Physiology-Heart and Circulatory Physiology, 271( 6 Pt 2), H2462-8. eScholarID:1d16423
  • Knot H, Zimmermann P, Nelson MT. (1996). Extracellular K(+)-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels. Journal of Physiology, 492 ( Pt 2), 419-30. eScholarID:1d16429
  • Li J, Yasay G, Kau S, Ohnmacht C, Trainor D, Bonev A, Heppner T, Nelson MT. (1996). Studies of the K(ATP) channel opening activity of the new dihydropyridine compound 9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridined ione in bladder detrusor in vitro. Arzneimittel Forschung, 46( 5), 525-30. eScholarID:1d16428
  • Robertson B, Bonev A, Nelson MT. (1996). Inward rectifier K+ currents in smooth muscle cells from rat coronary arteries: block by Mg2+, Ca2+, and Ba2+. American Journal of Physiology-Heart and Circulatory Physiology, 271( 2 Pt 2), H696-705. eScholarID:1d16427
  • Rubart M, Patlak J, Nelson MT. (1996). Ca2+ currents in cerebral artery smooth muscle cells of rat at physiological Ca2+ concentrations. Journal of General Physiology, 107( 4), 459-72. eScholarID:1d16430
  • Wellman G, Bonev A, Nelson MT, Brayden J. (1996). Gender differences in coronary artery diameter involve estrogen, nitric oxide, and Ca(2+)-dependent K+ channels. Circulation Research, 79( 5), 1024-30. eScholarID:1d16424
  • Wellman G, Brayden J, Nelson MT. (1996). A proposed mechanism for the cardioprotective effect of oestrogen in women: enhanced endothelial nitric oxide release decreases coronary artery reactivity. Clinical and Experimental Pharmacology and Physiology, 23( 3), 260-6. eScholarID:1d16431

1995

  • Kleppisch T, Nelson MT. (1995). Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences USA, 92( 26), 12441-5. eScholarID:1d16432
  • Kleppisch T, Nelson MT. (1995). ATP-sensitive K+ currents in cerebral arterial smooth muscle: pharmacological and hormonal modulation. American Journal of physiology-Heart and Circulatory Physiology, 269( 5 Pt 2), H1634-40. eScholarID:1d16433
  • Knot H, Nelson MT. (1995). Regulation of membrane potential and diameter by voltage-dependent K+ channels in rabbit myogenic cerebral arteries. American Journal of Physiology-Heart and Circulatory Physiology, 269( 1 Pt 2), H348-55. eScholarID:1d16436
  • Nelson MT, Cheng H, Rubart M, Santana L, Bonev A, Knot H, Lederer W. (1995). Relaxation of arterial smooth muscle by calcium sparks. Science, 270( 5236), 633-7. eScholarID:1d16435
  • Nelson MT, Quayle J. (1995). Physiological roles and properties of potassium channels in arterial smooth muscle. American Journal of Physiology-Cell Physiology, 268( 4 Pt 1), C799-822. eScholarID:1d16437
  • Quayle J, Bonev A, Brayden J, Nelson MT. (1995). Pharmacology of ATP-sensitive K+ currents in smooth muscle cells from rabbit mesenteric artery. American Journal of Physiology-Cell Physiology, 269( 5 Pt 1), C1112-8. eScholarID:1d16434

1994

  • Conway M, Nelson MT, Brayden J. (1994). 2-Deoxyglucose-induced vasodilation and hyperpolarization in rat coronary artery are reversed by glibenclamide. American Journal of Physiology-Heart and Circulatory Physiology, 266( 4 Pt 2), H1322-6. eScholarID:1d16441
  • Daut J, Standen N, Nelson MT. (1994). The role of the membrane potential of endothelial and smooth muscle cells in the regulation of coronary blood flow. Journal of Cardiovascular Electrophysiology, 5( 2), 154-81. eScholarID:1d16443
  • Quayle J, Bonev A, Brayden J, Nelson MT. (1994). Calcitonin gene-related peptide activated ATP-sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A. Journal of Physiology, 475( 1), 9-13. eScholarID:1d16442
  • Robertson B, Nelson MT. (1994). Aminopyridine inhibition and voltage dependence of K+ currents in smooth muscle cells from cerebral arteries. American Journal of Physiology-Cell Physiology, 267( 6 Pt 1), C1589-97. eScholarID:1d16438
  • Zhang L, Bonev A, Mawe G, Nelson MT. (1994). Protein kinase A mediates activation of ATP-sensitive K+ currents by CGRP in gallbladder smooth muscle. American Journal of Physiology-Gastrointestinal and Liver Physiology, 267( 3 Pt 1), G494-9. eScholarID:1d16439
  • Zhang L, Bonev A, Nelson MT, Mawe G. (1994). Activation of ATP-sensitive potassium currents in guinea-pig gall-bladder smooth muscle by the neuropeptide CGRP. Journal of Physiology, 478 Pt 3, 483-91. eScholarID:1d16440

1993

  • Bonev A, Nelson MT. (1993). ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder. American Journal of Physiology-Cell Physiology, 264( 5 Pt 1), C1190-200. eScholarID:1d16449
  • Bonev A, Nelson MT. (1993). Muscarinic inhibition of ATP-sensitive K+ channels by protein kinase C in urinary bladder smooth muscle. American Journal of Physiology-Cell Physiology, 265( 6 Pt 1), C1723-8. eScholarID:1d16444
  • Nelson MT, Brayden J. (1993). Regulation of arterial tone by calcium-dependent K+ channels and ATP-sensitive K+ channels. Cardiovascular Drugs and Therapy, 7 Suppl 3, 605-10. eScholarID:1d16447
  • Quayle J, McCarron J, Asbury J, Nelson MT. (1993). Single calcium channels in resistance-sized cerebral arteries from rats. American Journal of Physiology-Cell Physiology, 264( 2 Pt 2), H470-8. eScholarID:1d16450
  • Quayle J, McCarron J, Brayden J, Nelson MT. (1993). Inward rectifier K+ currents in smooth muscle cells from rat resistance-sized cerebral arteries. American Journal of Physiology-Cell Physiology, 265( 5 Pt 1), C1363-70. eScholarID:1d16446
  • Robertson B, Schubert R, Hescheler J, Nelson MT. (1993). cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. American Journal of Physiology-Cell Physiology, 265( 1 Pt 1), C299-303. eScholarID:1d16448
  • Zhang L, Bonev A, Nelson MT, Mawe G. (1993). Ionic basis of the action potential of guinea pig gallbladder smooth muscle cells. American Journal of Physiology-Cell Physiology, 265( 6 Pt 1), C1552-61. eScholarID:1d16445

1992

  • Brayden J, Nelson MT. (1992). Regulation of arterial tone by activation of calcium-dependent potassium channels. Science, 256( 5056), 532-5. eScholarID:1d16453
  • Gollasch M, Hescheler J, Quayle J, Patlak J, Nelson MT. (1992). Single calcium channel currents of arterial smooth muscle at physiological calcium concentrations. American Journal of Physiology-Heart and Circulatory Physiology, 263( 5 Pt 1), C948-52. eScholarID:1d16451
  • Kamishima T, Nelson MT, Patlak J. (1992). Carbachol modulates voltage sensitivity of calcium channels in bronchial smooth muscle of rats. American Journal of Physiology-Cell Physiology, 263( 1 Pt 1), C69-77. eScholarID:1d16452
  • Nelson MT. (1992). Regulation of arterial tone by potassium channels. Japanese Journal of Pharmacology, 58 Suppl 2, 238P-242P. eScholarID:1d16454

1991

  • Brayden J, Quayle J, Standen N, Nelson MT. (1991). Role of potassium channels in the vascular response to endogenous and pharmacological vasodilators. Blood Vessels, 28( 1-3), 147-53. eScholarID:1d16459
  • Kovacs R, Nelson MT. (1991). ATP-sensitive K+ channels from aortic smooth muscle incorporated into planar lipid bilayers. American Journal of Physiology-Heart and Circulatory Physiology, 261( 2 Pt 2), H604-9. eScholarID:1d16457
  • Langton P, Nelson MT, Huang Y, Standen N. (1991). Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions. American Journal of Physiology-Heart and Circulatory Physiology, 260( 3 Pt 2), H927-34. eScholarID:1d16458
  • McCarron J, Quayle J, Halpern W, Nelson MT. (1991). Cromakalim and pinacidil dilate small mesenteric arteries but not small cerebral arteries. American Journal of Physiology-Heart and Circulatory Physiology, 261( 2 Pt 2), H287-91. eScholarID:1d16456
  • Worley J, Quayle J, Standen N, Nelson MT. (1991). Regulation of single calcium channels in cerebral arteries by voltage, serotonin, and dihydropyridines. American Journal of Physiology-Heart and Circulatory Physiology, 261( 6 Pt 2), H1951-60. eScholarID:1d16455

1990

  • Nelson MT, Huang Y, Brayden J, Hescheler J, Standen N. (1990). Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels. Nature, 344( 6268), 770-3. eScholarID:1d16461
  • Nelson MT, Patlak J, Worley J, Standen N. (1990). Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. American Journal of Physiology-Cell Physiology, 259( 1 Pt 1), C3-18. eScholarID:1d16460

1989

  • Huang Y, Quayle J, Worley J, Standen N, Nelson MT. (1989). External cadmium and internal calcium block of single calcium channels in smooth muscle cells from rabbit mesenteric artery. Biophysical Journal, 56( 5), 1023-8. eScholarID:1d16462
  • Nelson MT, Worley J. (1989). Dihydropyridine inhibition of single calcium channels and contraction in rabbit mesenteric artery depends on voltage. Journal of Physiology, 412, 65-91. eScholarID:1d16464
  • Standen N, Quayle J, Davies N, Brayden J, Huang Y, Nelson MT. (1989). Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle. Science, 245( 4914), 177-80. eScholarID:1d16463

1988

  • Kovacs R, Nelson MT, Simmerman H, Jones L. (1988). Phospholamban forms Ca2+-selective channels in lipid bilayers. Journal of Biological Chemistry, 263( 34), 18364-8. eScholarID:1d16465
  • Nelson MT, Standen N, Brayden J, Worley J. (1988). Noradrenaline contracts arteries by activating voltage-dependent calcium channels. Nature, 336( 6197), 382-5. eScholarID:1d16466
  • Zschauer A, van Breemen C, Bühler F, Nelson MT. (1988). Calcium channels in thrombin-activated human platelet membrane. Nature, 334( 6184), 703-5. eScholarID:1d16467

1987

  • Nelson MT. (1987). Effects of permeant ions and blockers on properties of single calcium channels from brains. Society of General Physiologists Series, 41, 215-30. eScholarID:1d16469
  • Talvenheimo J, Worley J, Nelson MT. (1987). Heterogeneity of calcium channels from a purified dihydropyridine receptor preparation. Biophysical Journal, 52( 5), 891-9. eScholarID:1d16468

1986

  • Apell H, Nelson MT, Marcus M, Läuger P. (1986). Effects of the ATP, ADP and inorganic phosphate on the transport rate of the Na+,K+-pump. Biochimica Biophysica Acta, 857(1), 105-115. eScholarID:1d16471
  • Nelson MT. (1986). Interactions of divalent cations with single calcium channels from rat brain synaptosomes. Journal of General Physiology, 87( 2), 201-22. eScholarID:1d16472
  • Worley J, Deitmer J, Nelson MT. (1986). Single nisoldipine-sensitive calcium channels in smooth muscle cells isolated from rabbit mesenteric artery. Proceedings of the National Academy of Sciences, 83( 15), 5746-50. eScholarID:1d16470

1984

  • Lederer W, Nelson MT. (1984). Sodium pump stoicheiometry determined by simultaneous measurements of sodium efflux and membrane current in barnacle. Journal of Physiology, 348, 665-77. eScholarID:1d16473
  • Nelson MT, French R, Krueger B. (1984). Voltage-dependent calcium channels from brain incorporated into planar lipid bilayers. Nature, 308( 5954), 77-80. eScholarID:1d16474
  • Nelson MT, Lederer W. (1984). Sodium-dependent calcium efflux and sodium-dependent current in perfused barnacle muscle single cells. Society of General Physiologists Series, 38, 365-71. eScholarID:1d16475
  • Nelson MT. (1984). Single calcium channels from rat brain in planar lipid bilayers. Progress in Clinical and Biological Research, 168, 59-64. eScholarID:1d16476

1983

  • Lederer W, Nelson MT. (1983). Effects of extracellular sodium on calcium efflux and membrane current in single muscle cells from the barnacle. Journal of Physiology, 341, 325-39. eScholarID:1d16477
  • Nelson MT, Roudna M, Bamberg E. (1983). Single K+-channel current measurements from brain synaptosomes in lipid bilayers. American Journal of Physiology-Cell Physiology, 245( 1), C151-6. eScholarID:1d16478

1982

  • Nelson MT, Blaustein M. (1982). GABA efflux from synaptosomes: effects of membrane potential, and external GABA and cations. Journal of Membrane Biology, 69( 3), 213-23. eScholarID:1d16479

1981

  • Nelson MT, Blaustein M. (1981). Effects of ATP and vanadate on calcium efflux from barnacle muscle fibres. Nature, 289( 5795), 314-6. eScholarID:1d16480

1980

  • Nelson MT, Blaustein M. (1980). Properties of sodium pumps in internally perfused barnacle muscle fibers. Journal of General Physiology, 75( 2), 183-206. eScholarID:1d16481