Professor Mark T. Nelson

Photograph of Mark T. Nelson

Professor of Cardiovascular Medicine

Cardiovascular Medicine
University of Manchester
Core Technology Facility (3rd floor)
46 Grafton Street
Manchester
M13 9NT
UK

Department of Pharmacology
University of Vermont
Given Building, Room B-303
89 Beaumont Avenue
Burlington VT 05405-0068
USA

Role

Professor of Cardiovascular Medicine, The University of Manchester

Professor and Chair of Pharmacology, Professor of Molecular Physiology and Biophysics, University of Vermont, Link to Homepage

Visiting Professor, Department of Oxford

Google Scholar Citation Index

Memberships of Committees and Professional Bodies

  • Vermont Academy of Science and Engineering
  • American Physiological Society
  • American Society for Biochemistry and Molecular Biology (ASBMB)
  • American Society for Pharmacology & Experimental Therapeutics (ASPET)
  • Biophysical Society
  • Council on Basic Sciences, American Heart Association
  • Society of General Physiologists
  • Society for Neuroscience
  • Associate of Medical School Pharmacology

Research

Membrane transport and ion channels. In particular, to apply molecular, physiological, biophysical and pharmacological approaches to understand the roles of ion channels and calcium signaling in the function and dysfunction of smooth muscle, with an emphasis on urinary bladder and neurovascular coupling.

Link to Google Scholar Citation Index

Methodological Knowledge

  • Electrophysiology (patch clamp/bilayer/microelectrode techniques)
  • In vitro contraction and pressurized artery measurements
  • High-speed confocal calcium imaging
  • Fluorescence microscopy
  • Transport measurements with radioisotope tracers
  • Immunohisto- and cytochemistry
  • In vivo urodynamic, blood pressure and local cerebral blood flow measurements in mice
  • State-of-the-art PCR techniques (standard PCR, RT-PCR, etc.)
  • Southern and Western blot

Teaching

  • Toxicology Pharm 272 (Spring 2007 - Present)
    Lectures on Animal Toxins: Reptiles. Approximately 30 undergraduate and graduate students. Lecture: 1.5 hours/year.
  • Medicinal Chemistry Pharm 328 (Spring 2007 - Present) Lectures on calcium channel inhibitors, approximately 10 undergraduate and graduate students. Lecture 2 hours/year.
  • Molecular and Cellular Pharmacology Pharm 290 (Spring 2007 - Present) Lecture on ryanodine receptors, 2 hours/year.
  • Cardiovascular Physiology (Fall 2006 - Present)
    Lectures on cardiovascular system function, disease, and pharmacological intervention. Topics include membrane structure and function, receptor/drug interactions, excitable membranes, muscle contraction, control by the autonomic and somatic nervous systems, cardiac cycle, and mechanics of vascular blood flow. Approximately 14 graduate students. Lecture: 10 hours/year.
  • Introductory to Pharmacology 201 (Fall 2007 - Present)
    Lectures on hyperlipidemia, gonadal hormones, thyroid, bone pharmacology, vitamins, adrenal hormones, diabetes. Approximately 14 undergraduate students. Lecture: 6 hours/year.
  • Graduate Course in Neurochemistry (Fall 2005 - Present)
    Lecture and Discussion Group: calcium as an intracellular messenger. 4 hour/semester.
  • College of Medicine Vermont Integrated Curriculum (Generations and NMGI) (2004-present)
    Lectures on hyperlipidemia, diabetes, adrenal and thyroid. 20 hours/year.
  • Medical Pharmacology 301 (Summer) (1986-present)
    Lectures on hyperlipidemia, gonadal hormones, thyroid, bone pharmacology, vitamins, adrenal hormones, diabetes. Approximately 35 medical students. Lecture and Conference: 12 hours/year.
  • Pharmacology for Physical Therapists, Pharmacology 190 (1986-2000)
    Spring lectures (5) on Hyperlipidemia, Steroids, and Cardiovascular drugs. Approximately 60 undergraduate students. Lecture 9 hours/ year.
  • Graduate Course in Molecular and Cellular Pharmacology, Pharmacology 290
    Lectures on ion channel and ion pump pharmacology and biophysics. Approximately 15 graduate students. Lecture 6 hours/year.
  • Graduate Course in Molecular and Cell Biology (1986-1998)
    Lectures on ion channels. 2 lectures (4 hours) per year to approximately 30 graduate students

Biography

6/96- Chair, Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT
7/95-5/96 Interim Chair, Department of Pharmacology, University of Vermont
5/93- Professor, Department of Molecular Physiology & Biophysics, University of Vermont (Secondary)
7/92- Professor, Department of Pharmacology, College of Medicine, University of Vermont
7/90-6/92 Associate Professor with Tenure, Department of Pharmacology, University of Vermont
6/86-6/90 Assistant Professor, Department of Pharmacology, University of Vermont
9/84-5/86 Assistant Professor, Department of Pharmacology, University of Miami School of Medicine, Miami, FL
11/82-8/84 Research Assistant Professor, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD. Sponsor: Professor B.K. Krueger
6/81-10/82 Research Fellow of the Alexander von Humboldt Stiftung, Fakultät für Biologie, Universität Konstanz, West Germany. Sponsor: Professor P. Läuger
4/80-5/81 Research Fellow of the American Heart Association, Dept. of Physiology, University of Maryland, Baltimore, MD. Sponsor: Professor M.P. Blaustein

Qualifications

1980 Ph.D., Neural Sciences Washington University, St. Louis, MO Advisor: Prof. M.P. Blaustein
1976 B.A., Mathematics & Biology with Honors Tufts University, Medford, MA
1973 Undergraduate studies Swarthmore College, Swarthmore, PA

Collaborators and affiliated staff

Adam Greenstein, British Heart Foundation Intermediate Clinical Research Fellow, Institute of Cardiovascular Sciences, University of Manchester

Publications

2014

  • Hill-Eubanks, D. C., Gonzales, A. L., Sonkusare, S. K., & Nelson, M. T. (2014). Vascular TRP channels: Performing under pressure and going with the flow. Physiology, 29(5), 343-360. DOI:10.1152/physiol.00009.2014. Publication link: 9a18f89b-c956-43ca-b9d8-955ae3b44543
  • Mercado, J., Baylie, R., Navedo, M. F., Yuan, C., Scott, J. D., Nelson, M. T., ... Santana, L. F. (2014). Local control of TRPV4 channels by akap150-targeted PKC in arterial smooth muscle. Journal of General Physiology, 143(5), 559-575. DOI:10.1085/jgp.201311050. Publication link: 06a1c232-9ed5-4403-bdbe-d9fe67965232
  • Mingin, G. C., Peterson, A., Erickson, C. S., Nelson, M. T., & Vizzard, M. A. (2014). Social stress induces changes in urinary bladder function, bladder NGF content, And generalized bladder inflammation in mice. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 307(7), R893-R900. DOI:10.1152/ajpregu.00500.2013. Publication link: ca81e036-5ac8-4622-8666-6a37c122a545
  • Nelson, M., Dunn, K. M., & Nelson, M. T. (2014). Neurovascular signaling in the brain and the pathological consequences of hypertension. American Journal of Physiology - Heart and Circulatory Physiology, 306(1), -H14. DOI:10.1152/ajpheart.00364.2013. Publication link: 2e336421-f90c-43e6-bfd4-3c627755d923
  • Nelson, M., Gonzales, A. L., Yang, Y., Sullivan, M. N., Sanders, L., Dabertrand, F., ... Earley, S. (2014). A PLCγ1-dependent, force-sensitive signaling network in the myogenic constriction of cerebral arteries. Science Signaling, 7(327), [ra49]. DOI:10.1126/scisignal.2004732. Publication link: c11ac1df-b8e5-4052-b945-375fe781fcc2
  • Nelson, M., Krishnamoorthy, G., Sonkusare, S. K., Heppner, T. J., & Nelson, M. T. (2014). Opposing roles of smooth muscle BK channels and ryanodine receptors in the regulation of nerve-evoked constriction of mesenteric resistance arteries. American Journal of Physiology - Heart and Circulatory Physiology, 306(7), H981-H988. DOI:10.1152/ajpheart.00866.2013. Publication link: d97b51cf-0b25-4457-a030-535e73235dc2
  • Nelson, M., Longden, T. A., Dabertrand, F., Hill-Eubanks, D. C., Hammack, S. E., & Nelson, M. T. (2014). Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K+ channel function. Proceedings of the National Academy of Sciences of the United States of America, 111(20), 7462-7467. DOI:10.1073/pnas.1401811111. Publication link: 3517a84f-54fb-40e4-9edf-18af7c059d8c
  • Nelson, M., Nausch, B., Rode, F., Jørgensen, S., Nardi, A., Korsgaard, M. P. G., ... Rønn, L. C. B. (2014). NS19504: A novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. Journal of Pharmacology and Experimental Therapeutics, 350(3), 520-530. DOI:10.1124/jpet.113.212662. Publication link: 8b19e509-d4b4-476e-817b-8f412cf8b440
  • Nelson, M., Sonkusare, S. K., Dalsgaard, T., Bonev, A. D., Hill-Eubanks, D. C., Kotlikoff, M. I., ... Nelson, M. T. (2014). AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension. Science Signaling, (333), [ra66]. DOI:10.1126/scisignal.2005052. Publication link: dcfd044c-b7d5-428e-8e7a-f6193e04879b

2013

  • Cipolla, M. J., Sweet, J. G., Gokina, N. I., White, S. L., & Nelson, M. T. (2013). Mechanisms of enhanced basal tone of brain parenchymal arterioles during early postischemic reperfusion: Role of ET-1-induced peroxynitrite generation. Journal of Cerebral Blood Flow and Metabolism, 33(10), 1486-1492. DOI:10.1038/jcbfm.2013.99. Publication link: 6cd756c0-c972-4aa5-835f-e007a3fd97ed | PubMed:23778163
  • Koide, M., Bonev, A. D., Nelson, M. T., & Wellman, G. C. (2013). Subarachnoid blood converts neurally evoked vasodilation to vasoconstriction in rat brain cortex. Acta neurochirurgica. Supplement, (115), 167-171. DOI:10.1007/978-3-7091-1192-5-32. Publication link: cde90840-0b8c-463c-af73-6686f78cd255 | PubMed:22890664
  • Nelson, M., Dabertrand, F., Hannah, R. M., Pearson, J. M., Hill-Eubanks, D. C., Brayden, J. E., & Nelson, M. T. (2013). Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles. Journal of Cerebral Blood Flow and Metabolism, 33(4), 479-482. DOI:10.1038/jcbfm.2013.9. Publication link: b46a50ed-2937-4a47-bc3a-bde92b9e3740 | PubMed:23385200
  • Nelson, M., Dabertrand, F., Nelson, M. T., & Brayden, J. E. (2013). Ryanodine Receptors, Calcium Signaling, and Regulation of Vascular tone in the cerebral parenchymal microcirculation. Microcirculation, 20(4), 307-316. DOI:10.1111/micc.12027. Publication link: ca6e60ec-3e80-4288-8180-2709185030e4 | PubMed:23216877
  • Nelson, M., Dunn, K. M., Hill-Eubanks, D. C., Liedtke, W. B., & Nelson, M. T. (2013). TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. Proceedings of the National Academy of Sciences of the United States of America, 110(15), 6157-6162. DOI:10.1073/pnas.1216514110. Publication link: ebaef683-289e-45e4-8b9c-499b949fe691 | PubMed:23530219

2012

  • Dabertrand, F., Nelson, M. T., & Brayden, J. E. (2012). Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels. Circulation Research, 110(2), 285-294. DOI:10.1161/CIRCRESAHA.111.258145. Publication link: 984d9738-076e-4350-a4fc-674438e9fef2 | PubMed:22095728
  • Nelson, M. T., Lavoie, B., Nausch, B., Zane, E., Leonard, M., Balemba, O., ... Mawe, G. (2012). Disruption of Gallbladder Smoth Muscle Function is an Early Feature in the Development of Cholesterol Gallstone Disease. Neurogastroenterology and Motility, 313-329. DOI:10.1111/j.1365-2982.2012.01935. Publication link: 6e3e44f7-0608-4b5a-858d-44ac57bc4c36
  • Nelson, M., Joshi, S., Nelson, M. T., & Werner, M. E. (2012). Amplified NO/cGMP-mediated relaxation and ryanodine receptor-to-BK Ca channel signalling in corpus cavernosum smooth muscle from phospholamban knockout mice. British Journal of Pharmacology, 165(2), 455-466. DOI:10.1111/j.1476-5381.2011.01569.x. Publication link: 93b2fa84-9ae2-4224-9865-109873c01f36 | PubMed:21718308
  • Nelson, M., Koide, M., Bonev, A. D., Nelson, M. T., & Wellman, G. C. (2012). Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+(BK) channels. Proceedings of the National Academy of Sciences of the United States of America, 109(21), E1387-E1395. DOI:10.1073/pnas.1121359109. Publication link: 18398edf-4254-4db5-bc09-ae553c1cc8cf | PubMed:22547803
  • Nelson, M., Nausch, L. W. M., Bonev, A. D., Heppner, T. J., Tallini, Y., Kotlikoff, M. I., & Nelson, M. T. (2012). Sympathetic nerve stimulation induces local endothelial Ca 2+ signals to oppose vasoconstriction of mouse mesenteric arteries. American Journal of Physiology - Heart and Circulatory Physiology, 302(3), H594-H602. DOI:10.1152/ajpheart.00773.2011. Publication link: 9456b3e7-39fb-4191-8ab8-c8dae4b15653 | PubMed:22140050
  • Nelson, M., Sonkusare, S. K., Bonev, A. D., Ledoux, J., Liedtke, W., Kotlikoff, M. I., ... Nelson, M. T. (2012). Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science, 336(6081), 597-601. DOI:10.1126/science.1216283. Publication link: 1fb2bf59-b580-4647-b1df-46ee143139b3

2011

  • Heppner, T. J., Layne, J. J., Pearson, J. M., Sarkissian, H., & Nelson, M. T. (2011). Unique properties of muscularis mucosae smooth muscle in guinea pig urinary bladder. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 301(2), R351-R362. DOI:10.1152/ajpregu.00656.2010. Publication link: 1389074f-e173-4763-ac62-a23d1a1175d4
  • Koide, M., Nystoriak, M. A., Krishnamoorthy, G., O'Connor, K. P., Bonev, A. D., Nelson, M. T., & Wellman, G. C. (2011). Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone. Journal of Cerebral Blood Flow and Metabolism, 31(1), 3-16. DOI:10.1038/jcbfm.2010.143. Publication link: f5d237d1-307d-46d4-9a53-63f5ad13e988
  • Longden, T. A., Dunn, K. M., Draheim, H. J., Nelson, M. T., Weston, A. H., & Edwards, G. (2011). Intermediate-conductance calcium-activated potassium channels participate in neurovascular coupling. British Journal of Pharmacology, 164(3), 922-923. DOI:10.1111/j.1476-5381.2011.01447.x. Publication link: 69b85f77-b119-4b2c-baf4-e9adac384e1e | PubMed:21506954
  • Nelson, M., Hannah, R. M., Dunn, K. M., Bonev, A. D., & Nelson, M. T. (2011). Endothelial SKCa and IKCa channels regulate brain parenchymal arteriolar diameter and cortical cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism, 31(5), 1175-1186. DOI:10.1038/jcbfm.2010.214. Publication link: 17fcf65a-ebab-45b9-a8c0-6f5272f087e4 | PubMed:21179072
  • Nelson, M., Hill-Eubanks, D. C., Werner, M. E., Heppner, T. J., & Nelson, M. T. (2011). Calcium signaling in smooth muscle. Cold Spring Harbor Perspectives in Biology, 3(9), 1-20. DOI:10.1101/cshperspect.a004549. Publication link: 2b69fc83-4a40-442e-9eee-aa6429e430a0 | PubMed:21709182
  • Nelson, M., Nystoriak, M. A., O'Connor, K. P., Sonkusare, S. K., Brayden, J. E., Nelson, M. T., & Wellman, G. C. (2011). Fundamental increase in pressure-dependent constriction of brain parenchymal arterioles from subarachnoid hemorrhage model rats due to membrane depolarization. American Journal of Physiology - Heart and Circulatory Physiology, 300(3), H803-H812. DOI:10.1152/ajpheart.00760.2010. Publication link: a5fe754d-c52b-41ad-9d4a-459d1c4a6751 | PubMed:21148767

2010

  • Dunn, K. M., & Nelson, M. T. (2010). Calcium and diabetic vascular dysfunction. Focus on "Elevated Ca 2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells". American Journal of Physiology - Cell Physiology, 298(2), C203-C205. DOI:10.1152/ajpcell.00499.2009. Publication link: f099a0f6-b334-442d-a4d2-8975bcc173a8
  • Dunn, K. M., & Nelson, M. T. (2010). Potassium channels and neurovascular coupling. Circulation Journal, 74(4), 608-616. DOI:10.1253/circj.CJ-10-0174. Publication link: 30aa250d-eed8-440d-b330-854217c37504
  • Girouard, H., Bonev, A. D., Hannah, R. M., Meredith, A., Aldrich, R. W., & Nelson, M. T. (2010). Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction. Proceedings of the National Academy of Sciences of the United States of America, 107(8), 3811-3816. DOI:10.1073/pnas.0914722107. Publication link: b77b019f-58db-4a73-b251-7e41199d66ae | PubMed:20133576
  • Lavoie, B., Balemba, O. B., Godfrey, C., Watson, C. A., Vassileva, G., Corvera, C. U., ... Mawe, G. M. (2010). Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels. Journal of Physiology, 588(17), 3295-3305. DOI:10.1113/jphysiol.2010.192146. Publication link: 4a182fc8-f007-48cd-ab06-bc9b47cfd1a4
  • Layne, J. J., Nausch, B., Olesen, S. P., & Nelson, M. T. (2010). BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 298(2), R378-R384. DOI:10.1152/ajpregu.00458.2009. Publication link: d934bbc9-8bea-40c0-ab66-217646b1e117
  • Lu, C., Diehl, S. A., Noubade, R., Ledoux, J., Nelson, M. T., Spach, K., ... Teuscher, C. (2010). Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America, 107(44), 18967-18972. DOI:10.1073/pnas.1008816107. Publication link: 39dc0346-0120-4f9d-ae2e-f6ed6ffdd95b | PubMed:20956310
  • Nelson, M. T., Ledoux, J., Taylor, M., Bonev, A. D., Hannah, R., Solodushko, V., ... Kotlikoff, M. I. (2010). Spining Disk Confocal Microscopy of Calcium Signalling in Blood Vessel Walls. Microscopy and Analysis (E M E A Edition), 24(2), 5-8. [PMID 22506097]. . Publication link: aeef031c-c760-4230-8221-8b02a2174c7a
  • Nelson, M. T., Zvara, P., Wright, A. J., Ursiny, M., Shapiro, B., Dagrosa, L. M., & Heppner, T. J. (2010). A non-anesthetized mouse model for recording sensory urinary bladder activity. Frontiers in Neurology, 1(127). DOI:10.3389/fneur.2010.0127. Publication link: 92d24850-9abe-4e51-b24b-0337b141b4f6
  • Nelson, M., Hill-Eubanks, D. C., Werner, M. E., & Nelson, M. T. (2010). Local elementary purinergic-induced Ca2+ transients: From optical mapping of nerve activity to local Ca2+ signaling networks. Journal of General Physiology, 136(2), 149-154. DOI:10.1085/jgp.201010402. Publication link: 211b971e-a6db-4300-989d-2436b8f8fbaa

2009

  • Cao, R., Nelson, M. T., Ramos, R., Moore, C. I., Brumberg, J. C., Higashikubo, B. T., ... Knoblich, U. (2009). Pinacidil induces vascular dilation and hyperemia in vivo and does not impact biophysical properties of neurons and astrocytes in vitro. Cleveland Clinic Journal of Medicine, 76(2), S80-S85. DOI:10.3949/ccjm.76.s2.16. Publication link: fbf57a2f-3b36-4480-a85c-2ada36bf0677
  • Heppner, T. J., Werner, M. E., Nausch, B., Vial, C., Evans, R. J., & Nelson, M. T. (2009). Nerve-evoked purinergic signalling suppresses action potentials, Ca2+ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle. Journal of Physiology, 587(21), 5275-5288. DOI:10.1113/jphysiol.2009.178806. Publication link: 76dfbefd-361a-499e-ba3f-da18840f86cd
  • Nelson, M., Straub, S. V., Girouard, H., Doetsch, P. E., Hannah, R. M., Wilkerson, M. K., & Nelson, M. T. (2009). Regulation of intracerebral arteriolar tone by Kv channels: Effects of glucose and PKC. American Journal of Physiology - Cell Physiology, 297(3), C788-C796. DOI:10.1152/ajpcell.00148.2009. Publication link: 65e0bb4b-465e-481c-94bd-5cbd7dcf8a2d

2008

  • Bartoo, A. C., Nelson, M. T., & Mawe, G. M. (2008). ATP induces guinea pig gallbladder smooth muscle excitability via the P2Y4 receptor and COX-1 activity. American Journal of Physiology - Gastrointestinal and Liver Physiology, 294(6), G1362-G1368. DOI:10.1152/ajpgi.00043.2008. Publication link: 40f088aa-532f-4853-bcb5-b909a33d5624
  • Brayden, J. E., Earley, S., Nelson, M. T., & Reading, S. (2008). Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow. Clinical and Experimental Pharmacology and Physiology, 35(9), 1116-1120. DOI:10.1111/j.1440-1681.2007.04855.x. Publication link: 0900cff3-77d7-4d2f-9bd7-1b2674a39ffb | PubMed:18215190
  • Brown, S. M., Bentcheva-Petkova, L. M., Liu, L., Hristov, K. L., Chen, M., Kellett, W. F., ... Petkov, G. V. (2008). β-Adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel. American Journal of Physiology - Renal Physiology, 295(4), F1149-F1157. DOI:10.1152/ajprenal.00440.2007. Publication link: 392b7d35-69a6-4c87-945a-86488db4ae6d
  • Ledoux, J., Bonev, A. D., & Nelson, M. T. (2008). Ca2+-activated K+ channels in murine endothelial cells: Block by intracellular calcium and magnesium. Journal of General Physiology, 131(2), 125-135. DOI:10.1085/jgp.200709875. Publication link: 80b9dfc0-3a51-4d26-a31b-eff19aeb0c40
  • Ledoux, J., Taylor, M. S., Bonev, A. D., Hannah, R. M., Solodushko, V., Shui, B., ... Nelson, M. T. (2008). Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections. Proceedings of the National Academy of Sciences of the United States of America, 105(28), 9627-9632. DOI:10.1073/pnas.0801963105. Publication link: 805d7fc5-26f1-41c2-82f1-36748e950be6
  • Michael, S. K., Surks, H. K., Wang, Y., Zhu, Y., Blanton, R., Jamnongjit, M., ... Mendelsohn, M. E. (2008). High blood pressure arising from a defect in vascular function. Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6702-6707. DOI:10.1073/pnas.0802128105. Publication link: 4bfa5653-aed3-4422-8642-7ac0ab74ba86
  • Nausch, L. W. M., Ledoux, J., Bonev, A. D., Nelson, M. T., & Dostmann, W. R. (2008). Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors. Proceedings of the National Academy of Sciences of the United States of America, 105(1), 365-370. DOI:10.1073/pnas.0710387105. Publication link: 22aba9b7-235d-4c62-9f5e-38ee3c2e3fb9
  • Nelson, M. T., Balemba, O. B., Bartoo, A. C., & Mawe, G. M. (2008). The role of mitochondria in spontaneous rhythmic activity and intracellular calcium waves in the guinea pig gallbladder smooth muscle. American Journal of Physiology: Gastrointestinal and Liver Physiology (Print), 294(2), G467-G476. DOI:10.1152/ajpi.00415.2007. Publication link: 59eb7105-2a7c-4a72-a5f1-712e61cdd133
  • Nelson, M., Layne, J. J., Werner, M. E., Hill-Eubanks, D. C., & Nelson, M. T. (2008). NFATc3 regulates BK channel function in murine urinary bladder smooth muscle. American Journal of Physiology - Cell Physiology, 295(3), C611-C623. DOI:10.1152/ajpcell.00435.2007. Publication link: 53553fd5-0a9f-4278-a5e9-4b789d526bec
  • Nelson, M., Werner, M. E., Meredith, A. L., Aldrich, R. W., & Nelson, M. T. (2008). Hypercontractility and impaired sildenafil relaxations in the BK Ca channel deletion model of erectile dysfunction. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 295(1), R181-R188. DOI:10.1152/ajpregu.00173.2008. Publication link: 8f75d3f7-8096-48df-8357-d365c94954c5
  • Obata, F., Tohyama, K., Bonev, A. D., Kolling, G. L., Keepers, T. R., Gross, L. K., ... Obrig, T. G. (2008). Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons. Journal of Infectious Diseases, 198(9), 1398-1406. DOI:10.1086/591911. Publication link: 5ca484b4-120a-4e30-b239-ea29cac025e6
  • Thorneloe, K. S., Knorn, A. M., Doetsch, P. E., Lashinger, E. S. R., Liu, A. X., Bond, C. T., ... Nelson, M. T. (2008). Small-conductance, Ca2+-activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 294(5), R1737-R1743. DOI:10.1152/ajpregu.00840.2006. Publication link: 92b7d5bb-1136-4b18-999b-0cf681ecc2f5

2007

  • Filosa, J. A., Nelson, M. T., & Gonzalez Bosc, L. V. (2007). Activity-dependent NFATc3 nuclear accumulation in pericytes from cortical parenchymal microvessels. American Journal of Physiology - Cell Physiology, 293(6), C1797-C1805. DOI:10.1152/ajpcell.00554.2006. Publication link: 58940225-bc5b-4b38-b81b-8a18b9fc1f06
  • Lavoie, B., Balemba, O. B., Nelson, M. T., Ward, S. M., & Mawe, G. M. (2007). Morphological and physiological evidence for interstitial cell of Cajal-like cells in the guinea pig gallbladder. Journal of Physiology, 579(2), 487-501. DOI:10.1113/jphysiol.2006.122861. Publication link: 278ad046-8a68-4abc-9e35-1e43ec2be2b5
  • Mandalà, M., Heppner, T. J., Bonev, A. D., & Nelson, M. T. (2007). Effect of endogenous and exogenous nitric oxide on calcium sparks as targets for vasodilation in rat cerebral artery. Nitric Oxide - Biology and Chemistry, 16(1), 104-109. DOI:10.1016/j.niox.2006.06.007. Publication link: d635b3a9-4d66-4465-92ef-9f849e54fb2c
  • Nelson, M. T., Morita, H., Honda, A., Inoue, R., Ito, Y., Abe, K., & Brayden, J. (2007). Membrane stretch-induced activation of a TRPM4-like nonselective cation channel in cerebral artery myocytes.Journal of Pharmacological Sciences, 103( 4). . Publication link: fd6b2b2b-5f5a-4eee-9fc9-72eef5f43223
  • Nelson, M., Werner, M. E., Knorn, A. M., Meredith, A. L., Aldrich, R. W., & Nelson, M. T. (2007). Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: Modulation by BK channels. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 292(1), R616-R624. DOI:10.1152/ajpregu.00036.2006. Publication link: 7e04689b-c46d-4159-95e4-a26a59449924
  • Straub, S. V., & Nelson, M. T. (2007). Astrocytic Calcium Signaling: The Information Currency Coupling Neuronal Activity to the Cerebral Microcirculation. Trends in Cardiovascular Medicine, 17(6), 183-190. DOI:10.1016/j.tcm.2007.05.001. Publication link: 6e084c93-97ec-4f74-81aa-86a20f8a4f6a

2006

  • Balemba, O. B., Heppner, T. J., Bonev, A. D., Nelson, M. T., & Mawe, G. M. (2006). Calcium waves in intact guinea pig gallbladder smooth muscle cells. American Journal of Physiology - Gastrointestinal and Liver Physiology, 291(4), G717-G727. DOI:10.1152/ajpgi.00035.2006. Publication link: 7a669711-69e7-4f0e-a4c0-1e025610c72d
  • Balemba, O. B., Salter, M. J., Heppner, T. J., Bonev, A. D., Nelson, M. T., & Mawe, G. M. (2006). Spontaneous electrical rhythmicity and the role of the sarcoplasmic reticulum in the excitability of guinea pig gallbladder smooth muscle cells. American Journal of Physiology - Gastrointestinal and Liver Physiology, 290(4), G655-G664. DOI:10.1152/ajpgi.00310.2005. Publication link: 68645941-f5cc-41d1-940a-9b9f870082e9
  • Braas, K. M., May, V., Zvara, P., Nausch, B., Kliment, J., Dana Dunleavy, J., ... Vizzard, M. A. (2006). Role for pituitary adenylate cyclase activating polypeptide in cystitis-induced plasticity of micturition reflexes. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 290(4), R951-R962. DOI:10.1152/ajpregu.00734.2005. Publication link: 10211927-3720-4201-9788-f5afc9764bf9
  • Earley, S., & Nelson, M. T. (2006). Central role of Ca2+-dependent regulation of vascular tone in vivo. Journal of Applied Physiology, 101(1), 10-11. DOI:10.1152/japplphysiol.00270.2006. Publication link: 239565b3-0cf2-451a-b06a-fa4ea222e37e
  • Filosa, J. A., Bonev, A. D., Straub, S. V., Meredith, A. L., Wilkerson, M. K., Aldrich, R. W., & Nelson, M. T. (2006). Local potassium signaling couples neuronal activity to vasodilation in the brain. Nature Neuroscience, 9(11), 1397-1403. DOI:10.1038/nn1779. Publication link: bf5a4137-45a0-4ddb-8ec5-ed7749f7801f
  • Ledoux, J., Werner, M. E., Brayden, J. E., & Nelson, M. T. (2006). Calcium-activated potassium channels and the regulation of vascular tone. Physiology, 21(1), 69-79. DOI:10.1152/physiol.00040.2005. Publication link: 88919f5d-ad30-4cb1-a2b8-365b7d33edef
  • Nelson, M., Straub, S. V., & Nelson, M. T. (2006). Molecular coding of Kv1 channels to oppose myogenic constriction. Circulation Research, 99(1), 13-14. DOI:10.1161/01.RES.0000233147.38981.90. Publication link: 6b7d3824-25f4-4119-8d76-e4f23dcc760f
  • Straub, S. V., & Nelson, M. T. (2006). A spoonful of sugar helps the KV channel activity go down. Journal of Physiology, 575(3), 691. DOI:10.1113/jphysiol.2006.118091. Publication link: 82534821-11b5-4281-a0c6-1407894455f9
  • Straub, S. V., Bonev, A. D., Wilkerson, M. K., & Nelson, M. T. (2006). Dynamic inositol trisphosphate-mediated calcium signals within astrocytic endfeet underlie vasodilation of cerebral arterioles. Journal of General Physiology, 128(6), 659-669. DOI:10.1085/jgp.200609650. Publication link: e1f42c03-69e6-4a38-8e2d-74d80d74794e
  • Wilkerson, M. K., Heppner, T. J., Bonev, A. D., & Nelson, M. T. (2006). Inositol trisphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology - Heart and Circulatory Physiology, 290(1), H240-H247. DOI:10.1152/ajpheart.01191.2004. Publication link: 1b82dcda-91a7-499d-9de6-41f4f562ac2c

2005

  • Earley, S., Heppner, T. J., Nelson, M. T., & Brayden, J. E. (2005). TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. Circulation Research, 97(12), 1270-1279. DOI:10.1161/01.RES.0000194321.60300.d6. Publication link: 25cfe365-3be7-4f80-9d69-a3a696cf9b7a
  • Heppner, T. J., Bonev, A. D., & Nelson, M. T. (2005). Elementary purinergic Ca2+ transients evoked by nerve stimulation in rat urinary bladder smooth muscle. Journal of Physiology, 564(1), 201-212. DOI:10.1113/jphysiol.2004.077826. Publication link: 9a52407f-82e8-44a1-a559-942f2e3c2c3b
  • Mokelke, E. A., Dietz, N. J., Eckman, D. M., Nelson, M. T., & Sturek, M. (2005). Diabetic dyslipidemia and exercise affect coronary tone and differential regulation of conduit and microvessel K+ current. American Journal of Physiology - Heart and Circulatory Physiology, 288(3), H1233-H1241. DOI:10.1152/ajpheart.00732.2004. Publication link: 18febc65-4964-4d3d-b37a-287b6ba6c5d6
  • Nelson, M. T., & Petkov, G. (2005). Differential regulation of Ca2+-activated K+ channels by beta-adrenoceptors in guinea pig urinary bladder smooth muscle.American Journal of Physiology-Cell Physiology, 288( 6). . Publication link: cdbaed4f-264b-447f-9aa5-95d46bff3886
  • Nelson, M. T., Gonzalez, B. L., Layne, J., & Hill-Eubanks, D. (2005). Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer.Journal of Biological Chemistry, 280( 28). . Publication link: 7fa28860-d0c8-4d83-8c6f-e3fc8674e6f1
  • Nelson, M. T., Heppner, T., Bonev, A., Eckman, D., Gomez, M., & Petkov, G. (2005). Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries.Pharmacology, 73( 1). . Publication link: 41567dad-fb29-4771-96bb-e0ffc8cdbd51
  • Nelson, M. T., Herrera, G., Etherton, B., & Nausch, B. (2005). Negative feedback regulation of nerve-mediated contractions by KCa channels in mouse urinary bladder smooth muscle.American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 289( 2). . Publication link: 1483b7e1-a46c-4d61-a75a-c5b6d99dcad2
  • Nelson, M., Thorneloe, K. S., Meredith, A. L., Knorn, A. M., Aldrich, R. W., & Nelson, M. T. (2005). Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. American Journal of Physiology - Renal Physiology, 289(3), F604-F610. DOI:10.1152/ajprenal.00060.2005. Publication link: bc53381b-3da1-4fc7-9aaa-1d1a116656f9
  • Petkov, G. V., Balemba, O. B., Nelson, M. T., & Mawe, G. M. (2005). Identification of a spontaneously active, Na+-permeable channel in guinea pig gallbladder smooth muscle. American Journal of Physiology - Gastrointestinal and Liver Physiology, 289(3), G501-G507. DOI:10.1152/ajpgi.00140.2005. Publication link: c91f42e1-250f-4c04-afc1-1789d1a89fc7
  • Thorneloe, K. S., & Nelson, M. T. (2005). Ion channels in smooth muscle: Regulators of intracellular calcium and contractility. Canadian Journal of Physiology and Pharmacology, 83(3), 215-242. DOI:10.1139/y05-016. Publication link: 4cba5672-9971-451a-b384-effb8fbf662c
  • Werner, M. E., Zvara, P., Meredith, A. L., Aldrich, R. W., & Nelson, M. T. (2005). Erectile dysfunction in mice lacking the large-conductance calcium-activated potassium (BK) channel. Journal of Physiology, 567(2), 545-556. DOI:10.1113/jphysiol.2005.093823. Publication link: 5e1f31ed-66fb-4fc8-9080-18c5b7e7aec8

2004

  • Etherton, B., Heppner, T. J., Cumming, J. R., & Nelson, M. T. (2004). Opposing effects of aluminum on inward-rectifier potassium currents in bean root-tip protoplasts. Journal of Membrane Biology, 198(1), 15-22. DOI:10.1007/s00232-004-0658-y. Publication link: 854af40f-dc0f-43f3-9f9c-7f4b9b642c68
  • Filosa, J. A., Bonev, A. D., & Nelson, M. T. (2004). Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling.Circulation Research, 95(10), e73-81. . Publication link: 86e6955c-2216-48d0-8e22-94fbb72fd26a
  • Meredith, A. L., Thorneloe, K. S., Werner, M. E., Nelson, M. T., & Aldrich, R. W. (2004). Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel. Journal of Biological Chemistry, 279(35), 36746-36752. DOI:10.1074/jbc.M405621200. Publication link: 65fc4f85-44a8-4519-879a-4dbbdcb0d3aa
  • Nelson, M. T., & Bonev, A. (2004). The beta1 subunit of the Ca2+-sensitive K+ channel protects against hypertension.Journal of Clinical Investigation, 113( 7). . Publication link: b3ed71fc-05dd-4148-adea-06ced8e9c539
  • Nelson, M., Gonzalez Bosc, L. V., Wilkerson, M. K., Bradley, K. N., Eckman, D. M., Hill-Eubanks, D. C., & Nelson, M. T. (2004). Intraluminal pressure is a stimulus for NFATc3 nuclear accumulation: Role of calcium, endothelium-derived nitric oxide, and cGMP-dependent protein kinase. Journal of Biological Chemistry, 279(11), 10702-10709. DOI:10.1074/jbc.M312920200. Publication link: 8746c1d4-5297-429d-817d-b38fc4abb94a
  • Nelson, M., Thorneloe, K. S., & Nelson, M. T. (2004). Properties of a tonically active, sodium-permeable current in mouse urinary bladder smooth muscle. American Journal of Physiology - Cell Physiology, 286(6), C1246-C1257. DOI:10.1152/ajpcell.00501.2003. Publication link: d6d9d20f-6931-434e-ba8f-ec6d67ed7a06

2003

  • Amberg, G. C., Bonev, A. D., Rossow, C. F., Nelson, M. T., & Santana, L. F. (2003). Modulation of the molecular composition of large conductance, Ca 2+ activated K+ channels in vascular smooth muscle during hypertension. Journal of Clinical Investigation, 112(5), 717-724. DOI:10.1172/JCI200318684. Publication link: 8a4bd985-c7b5-4e84-91c2-3b73f3b74ce5
  • Herrera, G. M., Pozo, M. J., Zvara, P., Petkov, G. V., Bond, C. T., Adelman, J. P., & Nelson, M. T. (2003). Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel. Journal of Physiology, 551(3), 893-903. DOI:10.1113/jphysiol.2003.045914. Publication link: 1d5ba62e-aedd-4d0f-a06d-119a52d7133e
  • Li, P. L., Lee, H. C., Nelson, M. T., Meininger, G. A., & Van Breemen, C. (2003). Novel Ca2+ signalling mechanisms in vascular myocytes: Symposium overview. Acta Physiologica Scandinavica, 179(4), 339-352. DOI:10.1046/j.0001-6772.2003.01216.x. Publication link: b0a3d6ce-12d5-4f5e-8723-918825a8a911
  • Nelson, M. T., Gomez, M., Bosc, L., Stevenson, A., Wilkerson, M., & Hill-Eubanks, D. (2003). Constitutively elevated nuclear export activity opposes Ca2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1.Journal of Biological Chemistry, 278( 47). . Publication link: 806bb895-f8ef-4bad-89ed-52c9a1a8f478
  • Nelson, M. T., Heppner, T., Herrera, G., Bonev, A., & Hill-Eubanks, D. (2003). Ca2+ sparks and K(Ca) channels: novel mechanisms to relax urinary bladder smooth muscle.Advances in experimental medicine and biology, 539( Pt A). . Publication link: d9751579-5627-4709-90bc-032669d6306d
  • Nelson, M., Hill-Eubanks, D. C., Gomez, M. F., Stevenson, A. S., & Nelson, M. T. (2003). NFAT regulation in smooth muscle. Trends in Cardiovascular Medicine, 13(2), 56-62. DOI:10.1016/S1050-1738(02)00212-8. Publication link: 9d7c27ea-63bc-4844-8836-b640c88fb3e2
  • Nelson, M., Taylor, M. S., Bonev, A. D., Gross, T. P., Eckman, D. M., Brayden, J. E., ... Nelson, M. T. (2003). Altered expression of small-conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure. Circulation Research, 93(2), 124-131. DOI:10.1161/01.RES.0000081980.63146.69. Publication link: a960f47d-d53c-41fc-a89f-a4ee94ca3b30
  • Parr, E., Pozo, M. J., Horowitz, B., Nelson, M. T., & Mawe, G. M. (2003). ERG K+ channels modulate the electrical and contractile activities of gallbladder smooth muscle. American Journal of Physiology - Gastrointestinal and Liver Physiology, 284(3), G392-G398. . Publication link: e659bcd2-dad0-4fe0-ba14-ae99b5ac1b0e
  • Thorneloe, K. S., & Nelson, M. T. (2003). Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. Journal of Physiology, 549(1), 65-74. DOI:10.1113/jphysiol.2003.039859. Publication link: 12ca1a38-eabd-4a35-a2e6-72e6fc2436dd
  • Wellman, G. C., & Nelson, M. T. (2003). Signaling between SR and plasmalemma in smooth muscle: Sparks and the activation of Ca2+-sensitive ion channels. Cell Calcium, 34(3), 211-229. DOI:10.1016/S0143-4160(03)00124-6. Publication link: 747173b2-5e3f-4859-9102-b6d9f0749c1e

2002

  • Herrera, G. M., & Nelson, M. T. (2002). Sarcoplasmic reticulum and membrane currents. Novartis Foundation Symposium, 246, 189-207. DOI:10.1002/0470853050.ch14. Publication link: 655b2645-fec9-4eeb-b6bb-a1fee9ceffcb
  • Nelson, M. T., & Herrera, G. (2002). Differential regulation of SK and BK channels by Ca(2+) signals from Ca(2+) channels and ryanodine receptors in guinea-pig urinary bladder myocytes.Journal of Physiology, 541( Pt 2). . Publication link: cf195849-5060-4f53-b6b8-0f8dbe10ca0d
  • Nelson, M. T., & Herrera, G. (2002). Molecular physiology: protecting the heart.Nature, 416( 6878). . Publication link: 2692ac49-0f6b-49c1-a9c8-020162bdc84c
  • Nelson, M. T., Pozo, M., Pérez, G., & Mawe, G. (2002). Ca(2+) sparks and BK currents in gallbladder myocytes: role in CCK-induced response.American Journal of Physiology-Gastrointestinal and Liver Physiology, 282( 1). . Publication link: 574598aa-86a7-462f-b8b1-276da080a67e
  • Nelson, M., Gomez, M. F., Stevenson, A. S., Bonev, A. D., Hill-Eubanks, D. C., & Nelson, M. T. (2002). Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle. Journal of Biological Chemistry, 277(40), 37756-37764. DOI:10.1074/jbc.M203596200. Publication link: 23743ef2-9160-4cfa-a10c-ab1cfc761563
  • Nelson, M., Heppner, T. J., Bonev, A. D., Fernando Santana, L., & Nelson, M. T. (2002). Alkaline pH shifts Ca2+ sparks to Ca2+ waves in smooth muscle cells of pressurized cerebral arteries. American Journal of Physiology - Heart and Circulatory Physiology, 283(6), H2169-H2176. . Publication link: b6d64763-5980-4462-867f-b61703dea0d3
  • Santana, L. F., Chase, E. G., Votaw, V. S., Nelson, M. T., & Greven, R. (2002). Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes. Journal of Physiology, 544(1), 57-69. DOI:10.1113/jphysiol.2002.020552. Publication link: a12f1784-44a7-4fb6-b364-28384a72739d
  • Wellman, G. C., Nathan, D. J., Saundry, C. M., Perez, G., Bonev, A. D., Penar, P. L., ... Nelson, M. T. (2002). Ca2+ sparks and their function in human cerebral arteries. Stroke, 33(3), 802-808. DOI:10.1161/hs0302.104089. Publication link: e664cedf-ca6b-41cb-b739-7d069f377f8d
  • Welsh, D. G., Morielli, A. D., Nelson, M. T., & Brayden, J. E. (2002). Transient receptor potential channels regulate myogenic tone of resistance arteries. Circulation Research, 90(3), 248-250. DOI:10.1161/hh0302.105662. Publication link: f47c3eb1-ea5c-4e7b-ba6f-440f13504666

2001

  • Nelson, M. T., Herrera, G., & Heppner, T. (2001). Voltage dependence of the coupling of Ca(2+) sparks to BK(Ca) channels in urinary bladder smooth muscle.American Journal of Physiology-Cell Physiology, 280( 3). . Publication link: 8566a04d-6072-4e1d-965c-e89bdcd6d415
  • Nelson, M. T., Pérez, G., & Bonev, A. (2001). Micromolar Ca(2+) from sparks activates Ca(2+)-sensitive K(+) channels in rat cerebral artery smooth muscle.American Journal of Physiology-Cell Physiology, 281( 6). . Publication link: 4894df74-b149-4cbd-bdc6-e7d7c0657fd3
  • Nelson, M. T., Petkov, G., Bonev, A., Heppner, T., Brenner, R., & Aldrich, R. (2001). Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle.Journal of Physiology, 537( Pt 2). . Publication link: c27646ef-3dc4-4ffd-80b0-74fa58cac2ff
  • Nelson, M. T., Petkov, G., Heppner, T., Bonev, A., & Herrera, G. (2001). Low levels of K(ATP) channel activation decrease excitability and contractility of urinary bladder.American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 280( 5). . Publication link: 14327e29-252d-47da-ad8c-0318bc943c36
  • Nelson, M. T., Wellman, G. C., Cartin, L., Eckman, D. M., Stevenson, A. S., Saundry, C. M., & Lederer, W. J. (2001). Membrane depolarization, elevated Ca(2+) entry, and gene expression in cerebral arteries of hypertensive rats. American Journal of Physiology-Heart & Circulatory Physiology, 281(6). . Publication link: 1d56c5b3-e751-4f9b-b75a-a9b32d2992d9
  • Nelson, M. T., Wellman, G., Santana, L., & Bonev, A. (2001). Role of phospholamban in the modulation of arterial Ca(2+) sparks and Ca(2+)-activated K(+) channels by cAMP.American Journal of Physiology-Cell Physiology, 281( 3). . Publication link: f8be535c-e350-40cc-8221-695ce8456a48
  • Nelson, M., Eckman, D. M., & Nelson, M. T. (2001). Potassium ions as vasodilators: Role of inward rectifier potassium channels. Circulation Research, 88(2), 132-133. . Publication link: 8dec64c5-bd7d-4dd8-b8fb-9c203f81fb96
  • Schubert, R., & Nelson, M. T. (2001). Protein kinases: Tuners of the BKCa channel in smooth muscle. Trends in Pharmacological Sciences, 22(10), 505-512. DOI:10.1016/S0165-6147(00)01775-2. Publication link: e60ab5b1-053c-4d04-964a-e7f9b6f2bccc
  • Stevenson, A. S., Cartin, L., Wellman, T. L., Dick, M. H., Nelson, M. T., & Lounsbury, K. M. (2001). Membrane depolarization mediates phosphorylation and nuclear translocation of CREB in vascular smooth muscle cells. Experimental Cell Research, 263(1), 118-130. DOI:10.1006/excr.2000.5107. Publication link: 097baee8-bf7a-40a5-a58b-a7d042fc5196
  • Stevenson, A. S., Gomez, M. F., Hill-Eubanks, D. C., & Nelson, M. T. (2001). NFAT4 movement in native smooth muscle. A role for differential Ca 2+ signaling. Journal of Biological Chemistry, 276(18), 15018-15024. DOI:10.1074/jbc.M011684200. Publication link: 4331f149-9a4c-4025-bca7-71ef921c72d5

2000

  • Bayguinov, O., Hagen, B., Bonev, A. D., Nelson, M. T., & Sanders, K. M. (2000). Intracellular calcium events activated by ATP in murine colonic myocytes. American Journal of Physiology - Cell Physiology, 279(1), C126-C135. . Publication link: c57db6e3-ac2f-44b5-a1d5-970e1831f26f
  • Gollasch, M., Löhn, M., Fürstenau, M., Nelson, M. T., Luft, F. C., & Haller, H. (2000). Ca2+ channels, ca2+ sparks, and regulation of arterial smooth muscle function. Zeitschrift fur Kardiologie, 89(2), II15-II19. . Publication link: e8eb97a7-2dbf-4154-aada-5334c4f97fa5
  • Gollasch, M., Löhn, M., Furstenau, M., Nelson, M. T., Luft, F. C., & Haller, H. (2000). Ca2+ channels, 'quantized' Ca2+ release, and differentiation of myocytes in the cardiovascular system. Journal of Hypertension, 18(8), 989-998. . Publication link: d8fe83f5-9bd9-44c7-a898-b03aa4cedba9
  • Hemming, J. M., Guarraci, F. A., Firth, T. A., Jennings, L. J., Nelson, M. T., & Mawe, G. M. (2000). Actions of histamine on muscle and ganglia of the guinea pig gallbladder. American Journal of Physiology - Gastrointestinal and Liver Physiology, 279(3), G622-G630. . Publication link: 67713674-a7a9-480a-8d9c-8ce38c679f48
  • Nelson, M. T., & Jaggar, J. (2000). Differential regulation of Ca(2+) sparks and Ca(2+) waves by UTP in rat cerebral artery smooth muscle cells.American Journal of Physiology-Cell Physiology, 279( 5). . Publication link: 60d3c22e-51a4-4cd0-baab-6edea09008ff
  • Nelson, M. T., Brenner, R., Peréz, G., Bonev, A., Eckman, D., Kosek, J., ... Aldrich, R. (2000). Vasoregulation by the beta1 subunit of the calcium-activated potassium channel.Nature, 407( 6806). . Publication link: 323ee74b-cbe4-4e90-a4d4-d9fa0d2968f2
  • Nelson, M. T., Cartin, L., & Lounsbury, K. (2000). Coupling of Ca(2+) to CREB activation and gene expression in intact cerebral arteries from mouse : roles of ryanodine receptors and voltage-dependent Ca(2+) channels.Circulation Research, 86( 7). . Publication link: 90854ca8-951a-48b5-a3ce-e563a5e6d0b8
  • Nelson, M. T., Firth, T., & Mawe, G. (2000). Pharmacology and modulation of K(ATP) channels by protein kinase C and phosphatases in gallbladder smooth muscle.American Journal of Physiology-Cell Physiology, 278( 5). . Publication link: 593bf3ff-f8b7-48c8-9552-9fdbc093a130
  • Nelson, M. T., Jaggar, J., Porter, V., & Lederer, W. (2000). Calcium sparks in smooth muscle.American Journal of Physiology-Cell Physiology, 278( 2). . Publication link: af0a3f31-2c02-4551-967e-976a8ecd33f8
  • Nelson, M., Herrera, G. M., Heppner, T. J., & Nelson, M. T. (2000). Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 279(1), R60-R68. . Publication link: bb2da578-831a-410b-98f8-000b20eb84eb
  • Nelson, M., Welsh, D. G., & Nelson, M. T. (2000). A case for myoendothelial gap junctions. Circulation Research, 87(6), 427-428. . Publication link: f555e0ab-7dee-428a-81b6-87befa12d84f
  • Welsh, D. G., Nelson, M. T., Eckman, D. M., & Brayden, J. E. (2000). Swelling-activated cation channels mediate depolarization of rat cerebrovascular smooth muscle by hyposmolarity and intravascular pressure. Journal of Physiology, 527(1), 139-148. . Publication link: 07cdd5d1-0b6a-4ea2-a25d-15748c96bba4
  • Zaritsky, J. J., Eckman, D. M., Wellman, G. C., Nelson, M. T., & Schwarz, T. L. (2000). Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K+ current in K+-mediated vasodilation. Circulation Research, 87(2), 160-166. . Publication link: 22253f65-bb0b-4af1-9541-ad15e456b928

1999

  • Bradley, K. K., Jaggar, J. H., Bonev, A. D., Heppner, T. J., Flynn, E. R., Nelson, M. T., & Horowitz, B. (1999). Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells.Journal of Physiology, 515, 3. . Publication link: 39ab561c-ce0b-4ac2-93fd-08e327818bec
  • Gokina, N. I., Knot, H. J., Nelson, M. T., & Osol, G. (1999). Increased Ca2+ sensitivity as a key mechanism of PKC-induced constriction in pressurized cerebral arteries. American Journal of Physiology - Heart and Circulatory Physiology, 277(3), H1178-H1188. . Publication link: 9165f184-c506-4904-9f79-313c25dfe47e
  • Jennings, L. J., Xu, Q. W., Firth, T. A., Nelson, M. T., & Mawe, G. M. (1999). Cholesterol inhibits spontaneous action potentials and calcium currents in guinea pig gallbladder smooth muscle. American Journal of Physiology - Gastrointestinal and Liver Physiology, 277(5), G1017-G1026. . Publication link: 91ca5a50-920d-4e2c-b924-d6b31b1881b2
  • Kotlikoff, M. I., Herrera, G., & Nelson, M. T. (1999). Calcium permeant ion channels in smooth muscle.Reviews of physiology, biochemistry and pharmacology, 134, 147-199. . Publication link: a57a3b2e-2f0f-4dba-9455-40c11fdf41d7
  • Nelson, M. T., Pérez, G., Bonev, A., & Patlak, J. (1999). Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries.Journal of General Physiology, 113( 2). . Publication link: 0a47fcf1-4be9-45d8-be1b-897fbb0081e3
  • Nelson, M., Knot, H. J., Lounsbury, K. M., Brayden, J. E., & Nelson, M. T. (1999). Gender differences in coronary artery diameter reflect changes in both endothelial Ca2+ and ecNOS activity. American Journal of Physiology - Heart and Circulatory Physiology, 276(3), H961-H969. . Publication link: 9e153674-d508-4016-98f8-0dfd41f9c6cd
  • Vichi, P., Whelchel, A., Knot, H., Nelson, M., Kolch, W., & Posada, J. (1999). Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and RaF activation. American Journal of Respiratory Cell and Molecular Biology, 20(1), 99-105. . Publication link: 383abe92-6ba7-4b85-a459-c19b823685d1

1998

  • Jaggar, J. H., Mawe, G. M., & Nelson, M. T. (1998). Voltage-dependent K+ currents in smooth muscle cells from mouse gallbladder. American Journal of Physiology - Gastrointestinal and Liver Physiology, 274(4), G687-G693. . Publication link: 715fdf2f-72a8-422f-ba5d-8626460be195
  • Knot, H. J., & Nelson, M. T. (1998). Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure. Journal of Physiology, 508(1), 199-209. . Publication link: 7b93f113-3e2b-40bd-9670-59050c47d327
  • Knot, H. J., Standen, N. B., & Nelson, M. T. (1998). Ryanodine receptors regulate arterial diameter and wall [Ca2+] in cerebral arteries of rat via Ca2+-dependent K+ channels. Journal of Physiology, 508(1), 211-221. . Publication link: a655b3d4-a232-4948-a9a6-a80376e8644b
  • Nelson, M. T. (1998). Bayliss, myogenic tone and volume-regulated chloride channels in arterial smooth muscle. Journal of Physiology, 507(3), 629. DOI:10.1111/j.1469-7793.1998.629bs.x. Publication link: 25e399b2-3be8-4e32-ac74-e3c01b579b8a
  • Nelson, M. T., Jaggar, J., & Stevenson, A. (1998). Voltage dependence of Ca2+ sparks in intact cerebral arteries.American Journal of Physiology-Cell Physiology, 274( 6 Pt 1). . Publication link: 076a6447-66da-4f70-b16f-f0cacb53006d
  • Nelson, M. T., Jaggar, J., Wellman, G., Heppner, T., Porter, V., Perez, G., ... Bonev, A. (1998). Ca2+ channels, ryanodine receptors and Ca(2+)-activated K+ channels: a functional unit for regulating arterial tone.Acta Physiologica Scandinavica, 164( 4). . Publication link: 85289380-9be2-41ba-a5c9-d9606985cc07
  • Nelson, M., Gollasch, M., Wellman, G. C., Knot, H. J., Jaggar, J. H., Damon, D. H., ... Nelson, M. T. (1998). Ontogeny of local sarcoplasmic reticulum Ca2+ signals in cerebral arteries: Ca2+ sparks as elementary physiological events. Circulation Research, 83(11), 1104-1114. . Publication link: 073b915c-2ade-4c90-a7ab-b8499c81e20b
  • Nelson, M., Porter, V. A., Bonev, A. D., Knot, H. J., Heppner, T. J., Stevenson, A. S., ... Nelson, M. T. (1998). Frequency modulation of Ca2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides. American Journal of Physiology - Cell Physiology, 274(5), C1346-C1355. . Publication link: f2c7b565-e007-4a09-8fba-d9cc181a8c82

1997

  • Gollasch, M., & Nelson, M. T. (1997). Voltage-dependent Ca2+ channels in arterial smooth muscle cells. Kidney and Blood Pressure Research, 20(6), 355-371. . Publication link: 95244c1e-78df-4257-8184-dd9b36615fad
  • Nelson, M. T., Conway, M. A., Knot, H. J., & Brayden, J. E. (1997). Chloride channel blockers inhibit myogenic tone in rat cerebral arteries. Journal of Physiology, 502(2), 259-264. DOI:10.1111/j.1469-7793.1997.259bk.x. Publication link: f7b3c035-7ac8-473c-b07a-6e268acc4d33
  • Nelson, M. T., Heppner, T., & Bonev, A. (1997). Ca(2+)-activated K+ channels regulate action potential repolarization in urinary bladder smooth muscle.American Journal of Physiology-Cell Physiology, 273( 1 Pt 1). . Publication link: af8bef3d-1b8d-49d9-8f29-3e8be41701ae
  • Nelson, M., Bonev, A. D., Jaggar, J. H., Rubart, M., & Nelson, M. T. (1997). Activators of protein kinase C decrease Ca2+ spark frequency in smooth muscle cells from cerebral arteries. American Journal of Physiology - Cell Physiology, 273(6), C2090-C2095. . Publication link: aa8b5740-8cc0-49d5-81f6-6eb925917dbb
  • Nelson, M., Zimmermann, P. A., Knot, H. J., Stevenson, A. S., & Nelson, M. T. (1997). Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats. Circulation Research, 81(6), 996-1004. . Publication link: dd544faa-3704-4b2a-80e9-5ec82a70c68f
  • Quayle, J. M., Nelson, M. T., & Standen, N. B. (1997). ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiological Reviews, 77(4), 1165-1232. . Publication link: 1a73e613-21a0-481d-9ab2-b0d1fe8c307d

1996

  • Aquilla, E., Whelchel, A., Knot, H. J., Nelson, M., & Posada, J. (1996). Activation of multiple mitogen-activated protein kinase signal transduction pathways by the endothelin B receptor requires the cytoplasmic tail. Journal of Biological Chemistry, 271(49), 31572-31579. DOI:10.1074/jbc.271.49.31572. Publication link: 5995c24f-335b-4be9-a99b-f02a9035417e
  • Heppner, T. J., Bonev, A., Li, J. H., Kau, S. T., & Nelson, M. T. (1996). Zeneca ZD6169 activates ATP-sensitive K+ channels in the urinary bladder of the guinea pig. Pharmacology, 53(3), 170-179. . Publication link: 9a089641-315f-463c-9299-6ed67248e5d3
  • Kleppisch, T., Winter, B., & Nelson, M. T. (1996). ATP-sensitive potassium channels in cultured arterial segments. American Journal of Physiology - Heart and Circulatory Physiology, 271(6), H2462-H2468. . Publication link: ce045ab4-5e01-4ea4-b596-258b1479d68f
  • Knot, H. J., Zimmermann, P. A., & Nelson, M. T. (1996). Extracellular K+-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K+ channels. Journal of Physiology, 492(2), 419-430. . Publication link: 6b094523-4b2e-4e1c-a241-59c88173fd9e
  • Nelson, M. T., Li, J., Yasay, G., Kau, S., Ohnmacht, C., Trainor, D., ... Heppner, T. (1996). Studies of the K(ATP) channel opening activity of the new dihydropyridine compound 9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2H,5H)-acridined ione in bladder detrusor in vitro.Arzneimittel Forschung, 46( 5). . Publication link: bde5087c-fc96-4122-88c1-89d86b922d6c
  • Nelson, M. T., Robertson, B., & Bonev, A. (1996). Inward rectifier K+ currents in smooth muscle cells from rat coronary arteries: block by Mg2+, Ca2+, and Ba2+.American Journal of Physiology-Heart and Circulatory Physiology, 271( 2 Pt 2). . Publication link: d25ad978-fdb6-46b7-b4cd-667983555d3c
  • Nelson, M. T., Wellman, G., Bonev, A., & Brayden, J. (1996). Gender differences in coronary artery diameter involve estrogen, nitric oxide, and Ca(2+)-dependent K+ channels.Circulation Research, 79( 5). . Publication link: 53985f4d-0f01-40ff-a4a5-b26c18096862
  • Nelson, M., Bonev, A. D., & Nelson, M. T. (1996). Vasoconstrictors inhibit ATP-sensitive K+ channels in arterial smooth muscle through protein kinase C. Journal of General Physiology, 108(4), 315-323. . Publication link: 41e40fc6-881e-4c8d-b5d3-b0afd050a7e1
  • Nelson, M., Rubart, M., Patlak, J. B., & Nelson, M. T. (1996). Ca2+ currents in cerebral artery smooth muscle cells of rat at physiological Ca2+ concentrations. Journal of General Physiology, 107(4), 459-472. . Publication link: e1bcf878-87c4-46d4-b8a4-7d03f5ecf0cc
  • Nelson, M., Wellman, G. C., Brayden, J. E., & Nelson, M. T. (1996). A proposed mechanism for the cardioprotective effect of oestrogen in women: Enhanced endothelial nitric oxide release decreases coronary artery reactivity. Clinical and Experimental Pharmacology and Physiology, 23(3), 260-266. . Publication link: 714b5fee-c17c-448c-a2af-ce373da0bb5b

1995

  • Kleppisch, T., & Nelson, M. T. (1995). Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America, 92(26), 12441-12445. DOI:10.1073/pnas.92.26.12441. Publication link: 07ea185c-150a-4cc2-a7a5-384950f69c03
  • Kleppisch, T., & Nelson, M. T. (1995). ATP-sensitive K+ currents in cerebral arterial smooth muscle: Pharmacological and hormonal modulation. American Journal of Physiology - Heart and Circulatory Physiology, 269(5), H1634-H1640. . Publication link: dc575da0-1d45-4de5-84f2-94f1c77fdcd9
  • Knot, H. J., & Nelson, M. T. (1995). Regulation of membrane potential and diameter by voltage-dependent K+ channels in rabbit myogenic cerebral arteries. American Journal of Physiology - Heart and Circulatory Physiology, 269(1), H348-H355. . Publication link: 99292538-99d0-40d6-9409-131977db4534
  • Nelson, M. T., & Quayle, J. M. (1995). Physiological roles and properties of potassium channels in arterial smooth muscle. American Journal of Physiology - Cell Physiology, 268(4), C799-C822. . Publication link: d1a9854b-c156-49a6-b21d-2147bbc0ba92
  • Nelson, M. T., Cheng, H., Rubart, M., Santana, L. F., Bonev, A. D., Knot, H. J., & Lederer, W. J. (1995). Relaxation of arterial smooth muscle by calcium sparks. Science, 270(5236), 633-637. . Publication link: 30445f06-5b24-44fe-a39f-2d70765e7068
  • Nelson, M. T., Li, J. H., Yasay, G. D., Zografos, P., Kau, S. T., Ohnmacht, C. J., ... Heppner, T. J. (1995). ZENECA ZD6169 and its analogs from a novel series of anilide tertiary carbinols: in vitro KATP channel opening activity in bladder detrusor. Pharmacology, 51, 33-42. . Publication link: dedc3c90-5511-4c60-bf18-eb91371fcfaf
  • Quayle, J. M., Bonev, A. D., Brayden, J. E., & Nelson, M. T. (1995). Pharmacology of ATP-sensitive K+ currents in smooth muscle cells from rabbit mesenteric artery. American Journal of Physiology - Cell Physiology, 269(5), C1112-C1118. . Publication link: a4ade9cc-15fb-499e-a24c-60f886de220e

1994

  • Conway, M. A., Nelson, M. T., & Brayden, J. E. (1994). 2-Deoxyglucose-induced vasodilation and hyperpolarization in rat coronary artery are reversed by glibenclamide. American Journal of Physiology - Heart and Circulatory Physiology, 266(4), H1322-H1326. . Publication link: 90d5d02e-f08c-4e10-a641-d0ed5379ea61
  • Daut, J., Standen, N. B., & Nelson, M. T. (1994). The role of the membrane potential of endothelial and smooth muscle cells in the regulation of coronary blood flow. Journal of Cardiovascular Electrophysiology, 5(2), 154-181. . Publication link: bd0d38a7-0205-4407-89a7-2914f2600468
  • Nelson, M. T., & Robertson, B. (1994). Aminopyridine inhibition and voltage dependence of K+ currents in smooth muscle cells from cerebral arteries.American Journal of Physiology-Cell Physiology, 267( 6 Pt 1). . Publication link: 60a456c4-6d48-4166-902d-639379828f68
  • Nelson, M. T., Zhang, L., Bonev, A., & Mawe, G. (1994). Protein kinase A mediates activation of ATP-sensitive K+ currents by CGRP in gallbladder smooth muscle.American Journal of Physiology-Gastrointestinal and Liver Physiology, 267( 3 Pt 1). . Publication link: f19b97a1-bfcb-4b87-abc4-ebd6bc0485f5
  • Quayle, J. M., Bonev, A. D., Brayden, J. E., & Nelson, M. T. (1994). Calcitonin gene-related peptide activated ATP-sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A. Journal of Physiology, 475(1), 9-13. . Publication link: 6b13abe3-a937-45b7-86c0-71d0950e1962
  • Zhang, L., Bonev, A. D., Nelson, M. T., & Mawe, G. M. (1994). Activation of ATP-sensitive potassium currents in guinea-pig gall-bladder smooth muscle by the neuropeptide CGRP. Journal of Physiology, 478(3), 483-491. . Publication link: 824c035a-9448-434f-8c66-0806599f2898

1993

  • Bonev, A. D., & Nelson, M. T. (1993). ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder. American Journal of Physiology - Cell Physiology, 264(5), C1190-C1200. . Publication link: 038543d5-ed56-40df-b17f-68f5116682a2
  • Nelson, M. T. (1993). Ca2+-activated potassium channels and ATP-sensitive potassium channels as modulators of vascular tone. Trends in Cardiovascular Medicine, 3(2), 54-60. DOI:10.1016/1050-1738(93)90037-7. Publication link: 1ac561b9-c66e-41a7-a702-3907b857682e
  • Nelson, M. T., & Bonev, A. (1993). Muscarinic inhibition of ATP-sensitive K+ channels by protein kinase C in urinary bladder smooth muscle.American Journal of Physiology-Cell Physiology, 265( 6 Pt 1). . Publication link: b78adaa9-2bd2-477d-9917-74648d416411
  • Nelson, M. T., & Bonev, A. D. (1993). Muscarinic inhibition of ATP-sensitive K+ channels by protein kinase C in urinary bladder smooth muscle. American Journal of Physiology: Cell Physiology (Print), 265(6), C1723-C1728. [8279533]. . Publication link: 9357c5ce-8fc2-464a-a8ac-64071e8c35e9
  • Nelson, M. T., & Brayden, J. E. (1993). Regulation of arterial tone by calcium-dependent K+ channels and ATP-sensitive K+ channels. Cardiovascular Drugs and Therapy, 7(3), 605-610. DOI:10.1007/BF00877627. Publication link: f1bc6e67-9cb9-475f-bcf7-ea6799dd1522
  • Nelson, M. T., Quayle, J., McCarron, J., & Brayden, J. (1993). Inward rectifier K+ currents in smooth muscle cells from rat resistance-sized cerebral arteries.American Journal of Physiology-Cell Physiology, 265( 5 Pt 1). . Publication link: 8f09aebf-b804-4afe-a9d2-efc3d12e4326
  • Nelson, M. T., Zhang, L., Bonev, A., & Mawe, G. (1993). Ionic basis of the action potential of guinea pig gallbladder smooth muscle cells.American Journal of Physiology-Cell Physiology, 265( 6 Pt 1). . Publication link: fa63ed9a-c7b9-4558-8e2e-8743908e8e72
  • Quayle, J. M., McCarron, J. G., Asbury, J. R., & Nelson, M. T. (1993). Single calcium channels in resistance-sized cerebral arteries from rats. American Journal of Physiology - Heart and Circulatory Physiology, 264(2), H470-H478. . Publication link: 30141870-fafb-494e-b321-106d36fd3774
  • Robertson, B. E., Schubert, R., Hescheler, J., & Nelson, M. T. (1993). cGMP-Dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. American Journal of Physiology - Cell Physiology, 265(1), C299-C303. . Publication link: 097323f4-34d1-4bd2-b895-98e758c8d94f

1992

  • Brayden, J. E., & Nelson, M. T. (1992). Regulation of arterial tone by activation of calcium-dependent potassium channels. Science, 256(5056), 532-535. . Publication link: 64938af1-aaf2-4827-9b2b-e37da66d4a32
  • Gollasch, M., Hescheler, J., Quayle, J. M., Patlak, J. B., & Nelson, M. T. (1992). Single calcium channel currents of arterial smooth muscle at physiological calcium concentrations. American Journal of Physiology - Cell Physiology, 263(5), C948-C952. . Publication link: 8e4a0844-3411-4a15-b2c3-3319ab443aae
  • Kamishima, T., Nelson, M. T., & Patlak, J. B. (1992). Carbachol modulates voltage sensitivity of calcium channels in bronchial smooth muscle of rats. American Journal of Physiology - Cell Physiology, 263(1), C69-C77. . Publication link: 62c9f4b7-7168-4e61-83f7-cd5bfb8d9c69
  • Nelson, M. T. (1992). Regulation of arterial tone by potassium channels.Japanese Journal of Pharmacology, 58 Suppl 2. . Publication link: 67ebcb29-0426-403d-ad18-76b52211ae2c

1991

  • Brayden, J. E., Quayle, J. M., Standen, N. B., & Nelson, M. T. (1991). Role of potassium channels in the vascular response to endogenous and pharmacological vasodilators. Blood Vessels, 28(1-3), 147-153. . Publication link: 571b57e5-9d06-4b9f-b3c7-7ac4bb6fb93d
  • Kovacs, R. J., & Nelson, M. T. (1991). ATP-sensitive K+ channels from aortic smooth muscle incorporated into planar lipid bilayers. American Journal of Physiology - Heart and Circulatory Physiology, 261(2), H604-H609. . Publication link: c9ebbbc7-e8b2-4959-961c-fcb1f650332c
  • Langton, P. D., Nelson, M. T., Huang, Y., & Standen, N. B. (1991). Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions. American Journal of Physiology - Heart and Circulatory Physiology, 260(3), H927-H934. . Publication link: b95e2ba2-3f0e-4794-b18f-b8e79342ca26
  • McCarron, J. G., Quayle, J. M., Halpern, W., & Nelson, M. T. (1991). Cromakalim and pinacidil dilate small mesenteric arteries but not small cerebral arteries. American Journal of Physiology - Heart and Circulatory Physiology, 261(2), H287-H291. . Publication link: 96e3cc56-6fec-4fd3-8b58-15ce8f7ef41d
  • Worley, J. F., Quayle, J. M., Standen, N. B., & Nelson, M. T. (1991). Regulation of single calcium channels in cerebral arteries by voltage, serotonin, and dihydropyridines. American Journal of Physiology - Heart and Circulatory Physiology, 261(6), H1951-H1960. . Publication link: 191af753-4d9b-4571-bf22-2fdeb35589d8

1990

  • Nelson, M. T., Huang, Y., Brayden, J. E., Hescheler, J., & Standen, N. B. (1990). Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels. Nature, 344(6268), 770-773. . Publication link: 0e0a2b12-2de3-4286-9ee2-bbada182e731
  • Nelson, M. T., Patlak, J. B., Worley, J. F., & Standen, N. B. (1990). Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. American Journal of Physiology - Cell Physiology, 259(1), -C18. . Publication link: f11cdbea-4bdb-4f70-87b8-42b5a4685e9b

1989

  • Huang, Y., Quayle, J. M., Worley, J. F., Standen, N. B., & Nelson, M. T. (1989). External cadmium and internal calcium block of single calcium channels in smooth muscle cells from rabbit mesenteric artery. Biophysical Journal, 56(5), 1023-1028. . Publication link: 8d2775c3-41b4-4907-8f81-e00cd6904b6d
  • Nelson, M. T., & Worley, J. F. (1989). Dihydropyridine inhibition of single calcium channels and contraction in rabbit mesenteric artery depends on voltage. Journal of Physiology, 412, 65-91. . Publication link: 250a04f9-8029-4344-862c-04cc72b1ee10
  • Standen, N. B., Quayle, J. M., Davies, N. W., Brayden, J. E., Huang, Y., & Nelson, M. T. (1989). Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle. Science, 245(4914), 177-180. . Publication link: 14e979bc-3b21-4703-b68a-eb5c0955b0eb

1988

  • Kovacs, R. J., Nelson, M. T., Simmerman, H. K. B., & Jones, L. R. (1988). Phospholamban forms Ca2+-selective channels in lipid bilayers. Journal of Biological Chemistry, 263(34), 18364-18368. . Publication link: 9b68a200-ab63-490e-80fc-12063667edac
  • Nelson, M. T., Standen, N. B., Brayden, J. E., & Worley, J. F. (1988). Noradrenaline contracts arteries by activating voltage-dependent calcium channels. Nature, 336(6197), 382-385. DOI:10.1038/336382a0. Publication link: 52c80076-b3ea-4836-b09d-f01d2da810cf
  • Zschauer, A., Van Breemen, C., Buhler, F. R., & Nelson, M. T. (1988). Calcium channels in thrombin-activated human platelet membrane. Nature, 334(6184), 703-705. . Publication link: e1a02529-042f-4ae8-8491-91ebbe01df57

1987

  • Nelson, M. T. (1987). Effects of permeant ions and blockers on properties of single calcium channels from brains.Society of General Physiologists series, 41, 215-230. . Publication link: f8adead8-3a31-4a36-b1ee-e0fb87023bef
  • Talvenheimo, J. A., Worley, J. F., & Nelson, M. T. (1987). Heterogeneity of calcium channels from a purified dihydropyridine receptor preparation.Biophysical Journal, 52(5), 891-899. . Publication link: 0260f5cc-8872-48fc-a242-a1f45a8c3b22

1986

  • Apell, H. J., Nelson, M. T., Marcus, M. M., & Läuger, P. (1986). Effects of the ATP, ADP and inorganic phosphate on the transport rate of the Na+,K+-pump. Biochimica et Biophysica Acta - Biomembranes, 857(1), 105-115. . Publication link: 9235da90-d17d-42ae-a4db-8178db94e4c7
  • Nelson, M. T. (1986). Interactions of divalent cations with single calcium channels from rat brain synaptosomes. Journal of General Physiology, 87(2), 201-222. . Publication link: 8cef0aaf-dcd9-4e50-972b-6993cd8e0df2
  • Worley, J. F., Deitmer, J. W., & Nelson, M. T. (1986). Single nisoldipine-sensitive calcium channels in smooth muscle cells isolated from rabbit mesenteric artery. Proceedings of the National Academy of Sciences of the United States of America, 83(15), 5746-5750. . Publication link: 9d7a4616-ae91-4d33-94c4-c906f1453ff2

1984

  • Lederer, W. J., & Nelson, M. T. (1984). Sodium pump stoicheiometry determined by simultaneous measurements of sodium efflux and membrane current in barnacle. Journal of Physiology, 348, 665-677. . Publication link: 5f4eb044-6b19-42c0-9b78-71ddfd645c37
  • Nelson, M. T. (1984). Single calcium channels from rat brain in planar lipid bilayers.Progress in clinical and biological research, 168, 59-64. . Publication link: 5d9e10dd-596d-4762-93ca-338a24a588ce
  • Nelson, M. T., & Lederer, W. J. (1984). Sodium-dependent calcium efflux and sodium-dependent current in perfused barnacle muscle single cells.Society of General Physiologists series, 38, 365-371. . Publication link: 184a9f24-76cf-4121-9639-f55fcf73c2a4
  • Nelson, M. T., & Reinhardt, R. (1984). Single ion-channel current measurements from rat brain synaptosomes in planar lipid bilayers. Biophysical Journal, 45(1), 60-62. DOI:10.1016/S0006-3495(84)84108-9. Publication link: 9c02754a-107a-4d57-aff6-d5931d752b51
  • Nelson, M. T., French, R. J., & Krueger, B. K. (1984). Voltage-dependent calcium channels from brain incorporated into planar lipid bilayers. Nature, 308(5954), 77-80. . Publication link: a7815ccd-c5e7-4590-a77b-6bd7b96c0923

1983

  • Lederer, W. J., & Nelson, M. T. (1983). Effects of extracellular sodium on calcium efflux and membrane current in single muscle cells from the barnacle. Journal of Physiology, 341, 325-339. . Publication link: 0f2adb4d-cb1c-416c-bc72-842f6f69596a
  • Nelson, M. T., Roudna, M., & Bamberg, E. (1983). Single K+-channel current measurements from brain synaptosomes in lipid bilayers.American Journal of Physiology-Cell Physiology, 245( 1). . Publication link: 3e7ecb13-429a-4ea2-95a2-348dda8d838b

1982

1981

  • Nelson, M. T., & Blaustein, M. P. (1981). Effects of ATP and vanadate on calcium efflux from barnacle muscle fibres. Nature, 289(5795), 314-316. . Publication link: 39d83de6-ab31-4f41-95ca-f4684c89c653

1980

  • Nelson, M. T., & Blaustein, M. P. (1980). Properties of sodium pumps in internally perfused barnacle muscle fibers. Journal of General Physiology, 75(2), 183-206. . Publication link: 73d9b75b-ba3d-4ee2-a7fe-448a31b3bb12