Professor David Eisner M.A. D.Phil, FRCP (Hon), FMedSci

Photograph of David Eisner

BHF Professor of Cardiac Physiology

Research

Cardiovascular disease is the major cause of death in the developed world. David Eisner’s research group is trying to understand the mechanisms that regulate the contraction of the heart under both normal and diseased conditions. The heart is composed of billions of cells (myocytes) and, in order for it to pump blood these cells must contract synchronously. Contraction is initiated by an increase of the amount of calcium in the cell. Most of this calcium is released from an intracellular store. This group has defined the mechanisms that control the amount of calcium in the store and thence the amount that can be released to activate contraction. Current work is focused on changes in the store content of calcium in disease conditions.

Biography

David Eisner (B.A. Cambridge, Natural Sciences, 1976; D.Phil Oxford, Physiology, 1979).

He spent the period 1980- 1990 in the Department of Physiology at University College London. From 1990-1999 he was Professor of Veterinary Biology at Liverpool University before moving to Manchester as Professor of Cardiac Physiology in October 1999.

He has received the Pfizer Prize for Biology (1985), the Wellcome Prize in Physiology (1988) and given the QR Murphy lecture at the University of Wisconsin (1992), the Reimer Lecture of the International Society for Heart Research (2008), the Dorothy Wedgwood Lecture for Young People (2008), the  Peter Baker Memorial Lecture (2010), the Carmeliet-Coraboeuf-Weidmann Lecture of the European Working Group on Cardiac Cellular Electrophysiology (2013) and the GL Brown Lecture of the Physiological Society (2014).  He has been elected a Fellow of the Academy of Medical Sciences and  to Honorary Fellowship of the Royal College of Physicians.  He serves on the editorial board of  Cell Calcium and is a  Senior Consulting Editor of Circulation Research. He is the Editor in Chief of  The Journal of  Molecular and Cellular Cardiology. Until July 2000, he was Chairman of the Editorial Board of The Journal of Physiology. He was previously International Secretary of the Physiological Society and Chair of the British Society for Cardiovascular Research.  He was Chair of the Working Group of Cardiac Cellular Electrophysiology of the European Society of Cardiology and is the President of the Federation of European Physiological Societies (FEPS) and President-Elect of the International Society for Heart Research (European Section).  He chaired the International Scientific Programme Committe for the 2013 meeting of the International Union of Physiological Sciences (IUPS).  He has served on panels for the Research Assessment Exercise (RAE) in 2001 and 2008 and is currently a member of the Biological Sciences Panel for REF2014.

Publications

2015

  • Clarke, J. D., Caldwell, J. L., Horn, M. A., Bode, E. F., Richards, M. A., Hall, M. C. S., ... Trafford, A. W. (2015). Perturbed atrial calcium handling in an ovine model of heart failure: Potential roles for reductions in the L-type calcium current.Journal of molecular and cellular cardiology, 79. DOI:10.1016/j.yjmcc.2014.11.017. Publication link: 64e7fefa-7752-4c1a-b327-3465e027bb81 | PubMed:25463272
  • Dibb, K., Trafford, A., Zhang, H., & Eisner, D. (2015). A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 370(1666). DOI:10.1098/rstb.2014.0316. Publication link: db70282a-1e29-42fe-a40f-20da9d185957 | PubMed:25750236
  • Eisner, D. A., Miller, L., Greensmith, D. J., Sankaranarayanan, R., & O'Neill, S. C. (2015). The effect of 2,5-di(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca2+ handling in rat ventricular myocytes. Cell Calcium, 58(2), 208-14. . Publication link: b3c99c2c-fd10-4c88-b0f2-e490a3b27c8a
  • Miller, L., Greensmith, D. J., Sankaranarayanan, R., O'Neill, S. C., & Eisner, D. A. (2015). The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca2+ handling in rat ventricular myocytes.Cell calcium, 58(2). DOI:10.1016/j.ceca.2015.05.002. Publication link: 2907d472-96a3-4bdb-af7a-00c15378f357 | PubMed:26120055
  • Sankaranarayanan, R., Li, Y., Greensmith, D. J., Eisner, D. A., & Venetucci, L. (2015). Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak.The Journal of physiology. DOI:10.1113/JP271473. Publication link: 71e2e4c1-2e49-4f01-a573-a5e95b758826 | PubMed:26537441

2014

2013

2012

2011

  • Bode, E. F., Briston, S. J., Overend, C. L., O'Neill, S. C., Trafford, A. W., & Eisner, D. A. (2011). Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca 2+ content in rat ventricular myocytes. Journal of Physiology, 589(19), 4723-4729. DOI:10.1113/jphysiol.2011.211052. Publication link: f940c41e-87e0-45fd-bc6d-fc2155c80bf1 | PubMed:21825024
  • Briston, S. J., Caldwell, J. L., Horn, M. A., Clarke, J. D., Richards, M. A., Greensmith, D. J., ... Trafford, A. W. (2011). Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure. Journal of Physiology, 589(6), 1367-1382. DOI:10.1113/jphysiol.2010.203984. Publication link: 626417ab-4660-4c02-86d1-e3a46da0c154 | PubMed:21242250
  • Stokke, M. K., Briston, S. J., Jølle, G. F., Manzoor, I., Louch, W. E., Øyehaug, L., ... Sjaastad, I. (2011). Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content. Cardiovascular Research, 90(3), 503-512. DOI:10.1093/cvr/cvr013. Publication link: 83dadd85-86b8-4da8-b8a1-e15bb0cbc956 | PubMed:21242164

2010

  • Kashimura, T., Briston, S. J., Trafford, A. W., Napolitano, C., Priori, S. G., Eisner, D. A., & Venetucci, L. A. (2010). In the RyR2R4496C mouse model of CPVT, β-adrenergic stimulation induces ca waves by increasing SR Ca content and not by decreasing the threshold for Ca Waves. Circulation Research, 107(12), 1483-1489. DOI:10.1161/CIRCRESAHA.110.227744. Publication link: d8c22ad1-b8ad-4b33-8d8c-9df0ab99e13f | PubMed:20966392
  • Nirmalan, M., Greensmith, D. J., Eisner, D. A., & Nirmalan, M. (2010). The effects of hydrogen peroxide on intracellular calcium handling and contractility in the rat ventricular myocyte. Cell Calcium, 48(6), 341-351. DOI:10.1016/j.ceca.2010.10.007. Publication link: 2dbf3399-7762-4bd3-9b05-635dbdf52659 | PubMed:21106236
  • Stokke, M. K., Hougen, K., Sjaastad, I., Louch, W. E., Briston, S. J., Enger, U. H., ... Trafford, A. W. (2010). Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes. Cardiovascular Research, 86(1), 63-71. DOI:10.1093/cvr/cvp401. Publication link: ccd8dac8-0327-4b21-bac7-d3ed4e6eb6eb | PubMed:20019150

2009

2008

2007

2006

2005

2004

2003

2002

  • Eisner, D. A., & Trafford, A. W. (2002). Heart failure and the ryanodine receptor: does Occam's razor rule?. Circulation Research, 91. . Publication link: a71f6059-843d-4ba4-a7f8-3b8560c83245
  • O'Neill, S., Díaz, M. E., Eisner, D. A., & O'Neill, S. C. (2002). Depressed ryanodine receptor activity increases variability and duration of the systolic Ca2+ transient in rat ventricular myocytes. Circulation Research, 91(7), 585-593. DOI:10.1161/01.RES.0000035527.53514.C2. Publication link: 8fa0fc42-2ad8-47d7-ac25-65fe47135057
  • Smith, R. D., Eisner, D. A., & Wray, S. (2002). pH-induced changes in calcium: Functional consequences and mechanisms of action in guinea pig portal vein. American Journal of Physiology - Heart and Circulatory Physiology, 283(6), H2518-H2526. . Publication link: 3eb5a18d-930f-4c5a-9ad7-39a686fe42ce

2001

2000

  • Choi, H. S., Trafford, A. W., & Eisner, D. A. (2000). Measurement of calcium entry and exit in quiescent rat ventricular myocytes. Pflügers Archiv European Journal of Physiology, 440(4), 600-608. DOI:10.1007/s004240050011. Publication link: dbd36588-a1f6-4956-957f-721d5487c7ac
  • Choi, H. S., Trafford, A. W., Orchard, C. H., & Eisner, D. A. (2000). The effect of acidosis on systolic Ca2+ and sarcoplasmic reticulum calcium content in isolated rat ventricular myocytes. Journal of Physiology, 529(3), 661-668. DOI:10.1111/j.1469-7793.2000.00661.x. Publication link: 200b5ebc-f786-41d0-a167-ed8d744800f1
  • Diaz, M. E., Trafford, A. W., O'Neill, S. C., Eisner, D. A., Yano, M., & Yamamoto, T. (2000). Can changes of ryanodine receptor expression affect cardiac contractility? [2] (multiple letters). Cardiovascular Research, 45(4), 1068-1071. DOI:10.1016/S0008-6363(99)00412-5. Publication link: 10b7165d-c69b-4094-a9b3-bd05181dd531
  • Eisner, D. A., & Trafford, A. W. (2000). No role for the ryanodine receptor in regulating cardiac contraction?. News in Physiological Sciences, 15(5), 275-279. . Publication link: e11109b5-c612-4954-bee7-d32badb4080a
  • Eisner, D., Eisner, D. A., Choi, H. S., Díaz, M. E., O'Neill, S. C., & Trafford, A. W. (2000). Integrative analysis of calcium cycling in cardiac muscle. Circulation Research, 87(12), 1087-1094. . Publication link: 871e91cd-1f26-4cf8-a365-b9f506117450
  • Trafford, A. W., Eisner, D. A., Diaz, M. E., & Sibbring, G. C. (2000). Modulation of Ca-induced Ca release has not maintained effect on systolic Ca: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca fluxes in rat ventricular myocytes.Journal of Physiology, 522. . Publication link: d2f2467a-2741-4528-938c-db733ae4dc45
  • Trafford, A. W., Sibbring, G. C., Díaz, M. E., & Eisner, D. A. (2000). The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes. Cell Calcium, 28(4), 269-276. DOI:10.1054/ceca.2000.0156. Publication link: 766a6421-9ca8-4630-b39c-e3f1dc4e97be

1999

  • Trafford, A. W., Eisner, D. A., & Diaz, M. E. (1999). A novel, rapid and reversible method to measure Ca buffering and and timecourse of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes. Pflugers Archive, 437. . Publication link: 731ffea2-c744-48fe-be06-90bc1b781cdd

1998

  • Eisner, D. A., Overend, C. L., SC, O., & Neill, . U. (1998). The effect of tetracaine on stimulated contractions sr Ca2+ content and membrane current in isolated ventricular myocytes. Journal of Physiology-London, 507. . Publication link: 2f2e51c3-b9c4-4df6-8552-00fe12a3fcb0
  • Eisner, D. A., Shmigol, A. V., & Wray, S. (1998). Propoerties of voltage-gated CA2+-transients in single smooth muscle cells isolated from pregnant rat uterus. Journal of Physiology-London, 511. . Publication link: 501bceac-3002-4018-b5c1-8b690946aa13
  • Eisner, D. A., Shmigol, A., & Wray, S. (1998). Carboxyeosin decreases the rate of decay of the [Ca2+]transient in uterine smooth muscle cells isolated from pregnant rats. European Journal of Physiology, 437. . Publication link: 9022e2e5-4344-44ac-a7a3-1244f1b03f71
  • Eisner, D. A., Trafford, A. E., Diaz, M. E., & Negretti, N. (1998). Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of a Ca fluxes and sr Ca. Cardiovascular Research, 37. . Publication link: 0f494083-35a2-452b-a4bd-a37b0b70917c
  • Eisner, D. A., Trafford, A. W., Díaz, M. E., Overend, C. L., & O'Neill, S. C. (1998). The control of Ca release from the cardiac sarcoplasmic reticulum: Regulation versus autoregulation. Cardiovascular Research, 38(3), 589-604. DOI:10.1016/S0008-6363(98)00062-5. Publication link: 655a0314-67ac-47e0-a1e2-41c3d98b7382
  • Trafford, A. W., & Eisner, D. A. (1998). Another trigger for the heartbeat. Journal of Physiology, 513(1), 1. . Publication link: d0c2efd5-bdaf-438c-853f-7de71410e830
  • Trafford, A. W., Díaz, M. E., & Eisner, D. A. (1998). Ca-activated chloride current and Na-Ca exchange have different timecourses during sarcoplasmic reticulum Ca release in ferret ventricular myocytes. Pflügers Archiv European Journal of Physiology, 435(5), 743-745. DOI:10.1007/s004240050577. Publication link: 280841f8-a652-49ad-af18-19d7f0c1feff
  • Trafford, A. W., Diaz, M. E., & Eisner, D. A. (1998). Measurement of sarcoplasmic reticulum Ca content and sarcolemmal fluxes during the transient stimulation of the systolic Ca transient produced by caffeine. Annals of the New York Academy of Sciences, 853, 368-371. . Publication link: 1d54d1e4-4ee3-4524-86d0-6e090f176610
  • Trafford, A. W., Díaz, M. E., & Eisner, D. A. (1998). Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: Measurements of Ca fluxes and sarcoplasmic reticulum Ca. Cardiovascular Research, 37(3), 710-717. DOI:10.1016/S0008-6363(97)00266-6. Publication link: eb5ce918-59eb-46f2-b1dc-555623a00f7b
  • Trafford, A. W., Eisner, D. A., & Adams, W. (1998). 2,3-Butanedione monoxime (BDM)decreases sarcoplasmic reticulum Ca content bystimulating Ca release in isolated rat ventricular myocytes. Pflugers Archive, 436. . Publication link: 99bda4b9-99dc-4b51-a48b-f80207d3e3ab

1997

  • Díaz, M. E., Trafford, A. W., O'Neill, S. C., & Eisner, D. A. (1997). A measurable reduction of s.r. Ca content follows spontaneous Ca release in rat ventricular myocytes. Pflügers Archiv European Journal of Physiology, 434(6), 852-854. DOI:10.1007/s004240050475. Publication link: 10281be4-ca18-4ca7-a6ec-cf2d5965a7fa
  • Díaz, M. E., Trafford, A. W., O'Neill, S. C., & Eisner, D. A. (1997). Measurement of sarcoplasmic reticulum Ca2+ content and sarcolemmal Ca2+ fluxes in isolated rat ventricular myocytes during spontaneous Ca2+ release. Journal of Physiology, 501(1), 3-16. DOI:10.1111/j.1469-7793.1997.003bo.x. Publication link: e48967fe-50c9-48d9-a11c-1ef3701479bb
  • Eisner, D. A., Diaz, M. E., Trafford, A. W., SC, O., & Neill, . U. (1997). A measurable reduction of sr Ca content follows spontaneous Ca release in rat ventricular myocytes. Pflugers Archive, 434. . Publication link: 89106f7d-3953-421f-adfb-4bcb4e816ea0
  • Eisner, D. A., Elliott, A. C., & Smith, G. L. (1997). The contribution of intracellular acidosis to the decline of developed pressure in ferret hearts exposed to cyanide. Journal of Physiology-London, 391. . Publication link: d7d29526-84d5-4f5c-bd76-ad42aef5ae47
  • Eisner, D. A., Overend, C. L., SC, O., & Neill, . U. (1997). The effect of tetracaine on spontaneous Ca release and sarcoplasmic reticulum calcium content in rat ventricular myocytes. Journal of Physiology-London, 502. . Publication link: 15adefcc-b62e-456f-8170-b5f83b1ebd48
  • Eisner, D. A., Trafford, A. E., Diaz, M. E., & Negretti, N. (1997). Enhanced calcium current and decreased calcium efflux restore sarcoplasmic reticulum Ca content following depletion. Circulation Research, 81. . Publication link: 28730d79-be5d-45c8-84e2-f536d91a0e3e
  • Naderali, E. K., Buttell, N., Taggart, M. J., Bullock, A. J., Eisner, D. A., & Wray, S. (1997). The role of the sarcolemmal Ca2+-ATPase in the pH transients associated with contraction in rat smooth muscle. Journal of Physiology, 505(2), 329-336. DOI:10.1111/j.1469-7793.1997.329bb.x. Publication link: 731b24ce-5acc-4ae0-a5cf-ea1941edd574
  • Trafford, A. W., Díaz, M. E., Negretti, N., & Eisner, D. A. (1997). Enhanced Ca2+ current and decreased Ca2+ efflux restore sarcoplasmic reticulum Ca2+ content after depletion. Circulation Research, 81(4), 477-484. . Publication link: a4c12658-f2fc-454f-ba13-c4bf281d14d9

1996

  • Eisner, D. A., & Trafford, A. W. (1996). A sideways look at sparks, quarks, puffs and blips. Journal of Physiology, 497(1), 2. . Publication link: 7c6c4d1d-8d45-4105-b014-e5b59a6b6612
  • Eisner, D. A., Diaz, M. E., Cook, S. J., Chamunorwa, J. P., Trafford, A. W., Lancaster, M. K., ... Neill, . U. (1996). Variability of spontaneous Ca release between different rat ventricular myocytes is correlated with NA-Ca exchange and intracellular Na concentration. Circulation Research, 78. . Publication link: 1f82f260-a151-4ef0-b027-9b2691451333
  • Eisner, D., Díaz, M. E., Cook, S. J., Chamunorwa, J. P., Trafford, A. W., Lancaster, M. K., ... Eisner, D. A. (1996). Variability of Spontaneous Ca2+ Release Between Different Rat Ventricular Myocytes Is Correlated with Na+-Ca2+ Exchange and [Na+]i. Circulation Research, 78(5), 857-862. . Publication link: 6011800b-c6a9-4663-acc1-df5e814b2134
  • Lamont, C., & Eisner, D. A. (1996). The sarcolemmal mechanisms involved in the control of diastolic intracellular calcium in isolated rat cardiac trabeculae. Pflügers Archiv European Journal of Physiology, 432(6), 961-969. DOI:10.1007/s004240050223. Publication link: 3141e790-6881-459e-b0f6-c36e00becd4d

1995

  • Baro, I., & Eisner, D. A. (1995). Factors controlling changes in intracellular Ca2+ concentration produced by noradrenaline in rat mesenteric artery smooth muscle cells. Journal of Physiology, 482(2), 247-258. . Publication link: 2a3bfeb9-6b41-40f3-94e4-43d91f0e2cd9
  • Eisner, D. A., Negretti, N., & Varro, A. (1995). Estimate of net calcium fluxes and sarcoplasmic reticulum content during systole in rat ventricular myocytes. Journal of Physiology-London, 486. . Publication link: c86abfb9-4a15-4011-9e2d-f4472d520faf
  • Shmigol, A. V., Smith, R. D., Taggart, M. J., Wray, S., & Eisner, D. A. (1995). Changes of pH affect calcium currents but not outward potassium currents in rat myometrial cells. Pflügers Archiv European Journal of Physiology, 431(1), 135-137. DOI:10.1007/BF00374388. Publication link: dde009e7-127e-44cb-bf52-c68e5f09544e
  • Trafford, A. W., Diaz, M. E., O'Neill, S. C., & Eisner, D. A. (1995). Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes. Journal of Physiology, 488(3), 577-586. . Publication link: 3411be3f-2f57-4bff-80ed-f05cd983e7c2
  • Trafford, A. W., Lipp, P., O'Neill, S. C., Niggli, E., & Eisner, D. A. (1995). Propagating calcium waves initiated by local caffeine application in rat ventricular myocytes. Journal of Physiology, 489(2), 319-326. . Publication link: c270be82-cdfa-4472-9102-11be59243067

1994

  • Eisner, D. A., Donoso, P., SC, O., Neill, . U., Dilly, K. W., & Negretti, N. (1994). Comparison of the effects of caffeine and other methylxanthines on [Ca] in rat ventricular myocytes. British Journal of Pharmacology, 111. . Publication link: dcd30e65-83b4-4432-a800-ad72fe9a8eb0
  • Eisner, D. A., SC, O., Neill, . U., & Donoso, P. (1994). Properties of the fluorescent sodium indicator SBF1 in rant and rabbit cardic myocytes. Journal of Cardiovascular Electrophysiology, 5. . Publication link: aa7b1e30-020a-42de-bb56-64af0ec3b963
  • Orchard, C. H., Eisner, D. A., & Allen, D. G. (1994). Sydney Ringer viewed in a new light. Cardiovascular Research, 28(12), 1765-1768. . Publication link: 84165d67-270c-4cae-b5f1-0fe412190c03

1993

  • Baro, I., O'Neill, S. C., & Eisner, D. A. (1993). Changes of intracellular [Ca2+] during refilling of sarcoplasmic reticulum in rat ventricular and vascular smooth muscle. Journal of Physiology, 465, 21-41. . Publication link: d2147a60-dfd9-49a4-9057-a23bab879b8e
  • Eisner, D. A., Heaton, R. C., & Wray, S. (1993). Effects of metabolic inhibition and changes of intracellular pH on potassium permebility and contraction of rat uterus. Journal of Physiology-London, 456. . Publication link: ee25aee9-2d38-4f17-9840-f3fbcbb72796
  • Eisner, D. A., Negretti, N., SC, O., & Neill, . U. (1993). The effects of inhibitors of sarcoplasmic reticulum function on the size and time course of the systolic Ca transient in rat ventricular myocytes. Journal of Physiology-London, 468. . Publication link: 05c07e77-d4b8-45f1-9c3e-69a392f6595e
  • Eisner, D. A., Smith, G. L., & O'Neill, S. C. (1993). The effects of lactic acid production on contraction and intracellular pH during hypoxia in cardiac muscle. Basic Research in Cardiology, 88(5), 421-429. DOI:10.1007/BF00795409. Publication link: 10981d78-13fa-4564-8c7f-19f1825f9453
  • Eisner, D. A., Smith, G. L., Donoso, P., & Bauer, C. J. (1993). Relationship between intracellular pH and metabolic concentrations during metabolic inhibition in isolated ferret heart. Journal of Physiology-London, 472. . Publication link: 6efa5ff4-90c7-44c4-b602-c07e7a4287f2
  • Negretti, N., O'Neill, S. C., & Eisner, D. A. (1993). The relative contributions of different intracellular and sarcolemmal systems to relaxation in rat ventricular myocytes. Cardiovascular Research, 27(10), 1826-1830. . Publication link: 5b4289db-89fc-463b-bf92-72267791acb8
  • Trafford, A. W., O'Neill, S. C., & Eisner, D. A. (1993). Factors affecting the propagation of locally activated systolic Ca transients in rat ventricular myocytes. Pflügers Archiv European Journal of Physiology, 425(1-2), 181-183. DOI:10.1007/BF00374521. Publication link: 98da120b-b727-4a9b-a739-8f150eae1001
  • Varro, A., Negretti, N., Hester, S. B., & Eisner, D. A. (1993). An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytes. Pflügers Archiv European Journal of Physiology, 423(1-2), 158-160. DOI:10.1007/BF00374975. Publication link: 89a3324a-a2d1-4738-9cbf-e35b8d12af86

1992

  • Eisner, D. A., & Baro, I. (1992). The effects of thapsigargin on [Ca2+] in isolated rat mesenteric artery vascular smooth muscle cells. European Journal of Physiology, 420. . Publication link: 271e78b9-eea8-4d62-a1d2-db3b52e309bb
  • Eisner, D. A., Toescu, E., SC, O., Neill, . U., & Petersen, O. H. (1992). Caffeine inhibits the agonist-evoked cystolic Ca2+ signal in mouse pancreatic acinar cells by blocking inositol triosphsphate production. J. Biol. Chem., 267. . Publication link: 3a47b433-20f9-4b7a-b3ed-f588cf068300
  • Elliott, A. C., Smith, G. L., Eisner, D. A., & Allen, D. G. (1992). Metabolic changes during ischaemia and their role in contractile failure in isolated ferret hearts. Journal of Physiology, 454, 467-490. . Publication link: dd907bc5-a944-4bd3-a1ef-ecc03d10aca1

1991

  • Eisner, D. A., Eiesland, J., Baro, I., Raimbach, S., & Wray, S. (1991). Intracellular pH and buffering power measured inisolated single cells from pregnant rat uterus. Experimental Physiology, 76. . Publication link: 84fb9b48-3a93-4f05-9202-aa740fcca94a
  • O'Neill, S. C., Valdeolmillos, M., Lamont, C., Donoso, P., & Eisner, D. A. (1991). The contribution of Na-Ca exchange to relaxation in mammalian cardiac muscle. Annals of the New York Academy of Sciences, 639, 444-452. . Publication link: 615849f7-d41a-4c14-b92c-969c5df0c42e

1990

  • Eisner, D. A. (1990). The Wellcome prize lecture. Intracellular sodium in cardiac muscle: effects on contraction.Experimental Physiology, 75(4), 437-457. . Publication link: 134f9746-674f-4180-bd9a-9b86a80f2213
  • Eisner, D. A., SC, O., & Neill, . U. (1990). A mechanism for the effects of caffeine on Ca release during diastole and systole in isolated rat ventricular myocytes. Journal of Physiology-London, 40. . Publication link: 16925fc6-845f-4d36-86d4-7c52638912b7
  • Eisner, D. A., SC, O., Neill, . U., & Donoso, P. (1990). Local activation of contraction in isolated rat ventricular myocytes: measurement of [Ca2+] and [caffeine]. Journal of Physiology-London, 425. . Publication link: e87ee255-f31d-424a-824e-0b764c7175f4
  • Eisner, D. A., SC, O., Neill, . U., & Mill, J. G. (1990). Local activation of contraction in isolated rat ventricular myocytes. Am. J. Physiol, 258. . Publication link: a0a1a06c-c20d-4836-a6cb-4dd2f65a83a6
  • Eisner, D., Duchen, M. R., Valdeolmillos, M., & O'Neill, S. C. (1990). Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones. Journal of Physiology, 424, 411-426. . Publication link: 43956ccd-7bca-4ee2-ae23-8184e0613929

1989

  • Eisner, D. A., Briscoe, T. J., Duchen, M. R., SC, O., Neill, . U., & Valdeolmillos, M. (1989). Measurement of intracellular [Ca] in dissociated Type I cells of the rabbit carotid body. Journal of Physiology-London, 416. . Publication link: bba3a32a-7cd7-4d41-b845-d9b6e9354100
  • Eisner, D. A., Nichols, C. G., SC, O., Neill, . U., Smith, G. L., & Valdeolmillos, M. (1989). The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cells. Journal of Physiology-London, 411. . Publication link: a69fae64-ba37-4cf3-ba2c-450f264096fb
  • O'Neill, S. C., Valdeolmillos, M., Smith, G. L., & Eisner, D. A. (1989). The effects of metabolic inhibition on intracellular pH and Ca. Molecular and Cellular Biochemistry, 89(2), 199-203. DOI:10.1007/BF00220776. Publication link: 9d728026-a955-4199-9b0f-89d1e2b72be9
  • Valdeolmillos, M., O'Neill, S. C., Smith, G. L., & Eisner, D. A. (1989). Calcium-induced calcium release activates contraction in intact cardiac cells. Pflügers Archiv European Journal of Physiology, 413(6), 676-678. DOI:10.1007/BF00581820. Publication link: dea23c32-731c-4cf4-945c-15ec8e49da89

1988

  • Eisner, D. A., Elliott, A. C., & Smith, G. L. (1988). Do changes of intracellular pH contribute to the fall of force in myocardial hypoxia?. Biomedical Research, 9(2), 143-145. . Publication link: 2339b0b8-a0b8-4d38-bc07-6ad6cfb8af92
  • Eisner, D. A., Kenning, N. A., SC, O., Neill, . U., Pocock, G., Richards, C. D., & Valdeolmillos, M. (1988). A novel method for absolute measurement of intracellular pH applicable to any pH indicator. Pflugers Archive, 413. . Publication link: 95e82386-021c-4cd0-8893-77a2bf803f4b
  • Eisner, D. A., SC, O., Neill, . U., Valdeolmillos, M., & Allen, D. G. (1988). The effects of Ni on contraction and membrane current in isolated rat myocytes. Quarterly Journal of Experimental Physiology, 73. . Publication link: 9aae8d16-d330-443a-8198-8e14d9c157c3
  • Eisner, D. A., Smith, G. L., Valdeolmillos, M., & Allen, D. G. (1988). The effects of rapid application of caffeine on intracellular calcium concentration in ferret papillary muscles. Journal of General Physiology, 92. . Publication link: 2599388a-3b0c-4037-a16f-78e89f9d3aeb

1987

  • Eisner, D. A., Vaughan-Jones, R. D., & Lederer, W. J. (1987). Effects of changes of intracellular pH on contraction in sheep cardiac Purkinje fibres. Journal of General Physiology, 89. . Publication link: 8cbbd01d-92ab-43a2-841d-a549822f3894

1986

  • Allen, D. G., Eisner, D. A., & Morris, P. G. (1986). Metabolic consequences of increasing intracellular calcium and force production in perfused ferret hearts. Journal of Physiology, 376, 121-141. . Publication link: 954955e7-e739-413b-add7-41cefe3bf347
  • Cannell, M. B., Eisner, D. A., Lederer, W. J., & Valdeolmillos, M. (1986). Effects of membrane potential on intracellular calcium concentration in sheep Purkinje fibres in sodium-free solutions. Journal of Physiology, 381, 193-203. . Publication link: 97c2a20f-0084-4b04-959d-4e3d768283b8
  • Eisner, D. A. (1986). The role of intracellular Ca ions in the therapeutic and toxic effects of cardiac glycosides adn catecholamines. Journal of Cardiovascular Pharmacology, 8. . Publication link: 41993d7e-8628-454c-80dc-29d05dd32b56
  • Eisner, D. A., & Valdeolmillos, M. (1986). A study of intracellular calcium oscillations in sheep cardiac Purkinje fires. Journal of Physiology-London, 372. . Publication link: 5a52d488-5ac9-48f8-a3da-45fa0a08cef2
  • Eisner, D. A., & Valdeolmillos, M. (1986). Measurement of intracellular calcium during the development and spontaneous relaxation of tonic tension in sheep cardiac Purkinje fibres. Journal of Physiology-London, 375. . Publication link: 162fa3e4-46e6-4535-a805-8677027a282f
  • Eisner, D. A., Valdeolmillos, M., & Wray, S. C. (1986). The effects of membrane potential on active and passive sodium transport in xenopus oocytes. Journal of Physiology-London, 381. . Publication link: cccac3a9-92f7-4564-a6fd-1c61ed586faf

1985

  • Allen, D. G., Eisner, D. A., & Wray, S. C. (1985). Sodium pump: Birthday present for digitalis. Nature, 316(6030), 674-675. DOI:10.1038/316674a0. Publication link: 1bc61fa9-0d42-4aa3-9907-97989f8d841b
  • Allen, D. G., Eisner, D. A., Pirolo, J. S., & Smith, G. L. (1985). The relationship between intracellular calcium and contraction in calcium-overloaded ferret papillary muscles. Journal of Physiology, 364, 169-182. . Publication link: 814ab1f7-360f-4316-a588-f4bf896f4396
  • Eisner, D. A., & Lederer, W. J. (1985). Na-Ca exchange: stoichiometry and electrogenecity. Am. J. Physiol, 248. . Publication link: bb18cd35-8d7d-49e9-ab77-1b1032252d7a
  • Eisner, D. A., & Nieman, C. J. (1985). Effects of caffeine, tetracaine and ryanodine on calcium-dependent oscillations in sheep cardiac Purkinje fibres. Journal of General Physiology, 86. . Publication link: 0d5ec53a-4c9f-4220-ab00-36c4d37bdad2
  • Eisner, D. A., & Valdeolmillos, M. (1985). The mechanism of the increase of tonic tension produced by caffeine in sheep cardiac Purkinje fibres. Journal of Physiology, 364, 313-326. . Publication link: 599a14cb-9ed3-4756-abb7-ad5ee2541c24
  • Eisner, D. A., & Valdeolmilos, M. (1985). The effects of fyanodine on calcium-overloaded sheep cardiac Purkinje fibres. Circulation Research, 56. . Publication link: 8d077d6a-5d1d-4c5a-8b93-79ff4211a7d9
  • Eisner, D. A., Requena, J., Whitembury, J., Tiffert, T., & Mullins, L. J. (1985). The influence of chemical agents on the level of ionized [Ca++] in squid axons. Journal of General Physiology, 85. . Publication link: 9db169e7-6903-4b94-844f-527b3cc0c94d
  • Wray, S., Eisner, D. A., & Allen, D. G. (1985). Two hundred years of the foxglove.Medical history. Supplement, (5), 132-150. . Publication link: 7d8356f9-ec73-4739-bfda-7d10c68c41d5

1984

  • Allen, D. G., Eisner, D. A., & Orchard, C. H. (1984). Characterization of oscillations of intracellular calcium concentration in ferret ventricular muscle. Journal of Physiology, 352, 113-128. . Publication link: e5531a66-7744-44a4-8e06-1daa95420abd
  • Allen, D. G., Eisner, D. A., & Orchard, C. H. (1984). Factors influencing free intracellular calcium concentration in quiescent ferret ventricular muscle. Journal of Physiology, 350, 615-630. . Publication link: a493816c-f66e-4dff-b714-9d50e6535346
  • Eisner, D. A., & Wray, S. C. (1984). Ion pumping in biological membranes. Contemporary Physics, 26. . Publication link: 54bf310e-7dd2-4145-9c4f-da326cbecd5f
  • Eisner, D. A., Lederer, W. J., & Vaughan-Jones, R. D. (1984). The quantitative relationship between intracellular Na activity and tension in sheep cardiac Purkinje fibres. Journal of Physiology-London, 355. . Publication link: b4d024d2-f1f5-41eb-9250-6ae3e04b4c7d
  • Eisner, D. A., Orchard, C. H., & Allen, D. G. (1984). Control of intracellular ionized calcium concentration by sarcolemmal and intracellular mechnisms. Journal of Molecular and Cellular Cardiology, 16. . Publication link: 8c225d08-b4a1-408b-bfc1-bd56ce2a8f6a
  • Requena, J., Whittembury, J., Tiffert, T., Eisner, D. A., & Mullins, L. J. (1984). A comparison of measurements of intracellular Ca by Ca electrode and optical indicators. Biochimica et Biophysica Acta - Molecular Cell Research, 805(4), 393-404. . Publication link: 4172d441-b437-4917-a8bf-ef1aa3319269

1983

  • Eisner, D. A., & Richards, D. E. (1983). Stimulation and inhibition by ATP and orthophosphate of the potassium: potassium exchange in resealed red cell ghosts. Journal of Physiology-London, 335. . Publication link: c9c10e5f-ba0c-4db7-9d21-96eb74dc99b3
  • Eisner, D. A., & Vaughan-Jones, R. D. (1983). Do calcium-activated potassium channels exist in the heart?. Cell Calcium, 4(5-6), 371-386. . Publication link: 4d5a152d-ccdf-46a0-aaee-f2862a619239
  • Eisner, D. A., Allen, D. G., Lab, M. J., & Orchard, C. H. (1983). The effects of low Na solutions on intracellular Ca concentration and tension in ferret ventricular muscle. Journal of Physiology-London, 345. . Publication link: f2fab35c-0926-483b-b9e7-794d30d4e465
  • Eisner, D. A., Lederer, W. J., & Sheu, S-S. (1983). The role of intracellular sodium activity in the antiarrhythmic action of local anaesthetics in sheep cardiac Purkinje fibres. Journal of Physiology-London, 340. . Publication link: 9113ad90-bc18-41a7-95eb-828f481a5239
  • Eisner, D. A., Lederer, W. J., & Vaughan-Jones, R. D. (1983). The control of tonic tension by membrane potential and intracellular Na activity in the sheep cardiac Purkinje fibre. Journal of Physiology-London, 335. . Publication link: 24d5d2a3-be9b-41f4-8668-f74021a5bb4c
  • Eisner, D. A., Vaughan Jones, R. D., Lederer, W. J., & Smith, T. W. (1983). Comments on 'active transport and inotropic state in guinea pig left atrium' which appeared in Circ. res. 52: 411-422, 1983. Circulation Research, 53(6), 834-836. . Publication link: ccbb1214-1fb7-4b96-97ba-4acef358a317
  • Orchard, C. H., Eisner, D. A., & Allen, D. G. (1983). Oscillations of intracellular Ca2+ in mammalian cardiac muscle. Nature, 304(5928), 735-738. . Publication link: a0dd08cc-3af3-491d-857d-e5208e246735

1982

  • Arnold, L., Page, J., Attwell, D., Cannell, M., & Eisner, D. A. (1982). The dependence on heart rate of the human ventricular action potential duration. Cardiovascular Research, 16(10), 547-551. . Publication link: 278252fb-9e33-4702-b408-e8d507ad3df8
  • Eisner, D. A., & Richards, D. E. (1982). Inhibition of the sodium pump by inorganic phosphate in resealed red cell ghosts. Journal of Physiology, 326, 1-10. . Publication link: 311331e1-932c-4958-aba1-6c16b4b37b7e
  • Lederer, W. J., & Eisner, D. A. (1982). The effects of sodium pump activity on the slow inward current in sheep cardiac Purkinje fibres. Proceedings of the Royal Society B: Biological Sciences, 214(1195), 249-262. . Publication link: 750fd47c-00e9-441a-b411-e6a24e3fc9dd

1981

  • Attwell, D., Cohen, I., & Eisner, D. A. (1981). The effects of heart rate on the action potential of guinea-pig and human ventricular muscle. Journal of Physiology, 313, 439-461. . Publication link: 3bf9b60b-58c5-4c36-9da7-8b25676ea732
  • Eisner, D. A., & Richards, D. E. (1981). The interaction of potassium ions and TP with the sodium pump of resealed red cell ghosts. Journal of Physiology-London, 319. . Publication link: fdb09cff-0b85-4e88-9e1f-2585c6212bb2
  • Eisner, D. A., Lederer, W. J., & Vaughand-Jones, R. D. (1981). The effects of rubidium ions and membrane potential on the intracellular sodium activity of sheep Purkinje fibres. Journal of Physiology, 317, 189-205. . Publication link: 5331edb9-b81f-4b4c-b843-8301217fd051
  • Eisner, D. A., Lederer, W. J., & Vaughan-Jones, R. D. (1981). The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep cardiac Purkinje fibres. Journal of Physiology-London, 317. . Publication link: cd9e54c5-2465-49ae-9e93-d474027f83f8

1979

  • Attwell, D., Cohen, I., & Eisner, D. (1979). Membrane potential and ion concentration stability conditions for a cell with a restricted extracellular space. Proceedings of the Royal Society B: Biological Sciences, 206(1163), 145-161. . Publication link: 9666ac09-994c-4852-ab65-214998223612
  • Attwell, D., Cohen, I., Eisner, D., Ohba, M., & Ojeda, C. (1979). The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres. Pflügers Archiv European Journal of Physiology, 379(2), 137-142. DOI:10.1007/BF00586939. Publication link: 46a02db3-fb1a-459d-814e-fb51b751bce9
  • Eisner, D. A., & Lederer, W. J. (1979). Inotropic and arrhythmogenic effects of potassium-depleted solutions on mammalian cardiac muscle. Journal of Physiology, 294, 255-277. . Publication link: 21aef6b3-0905-4097-bfb0-3c8ba42b9c43
  • Eisner, D. A., & Lederer, W. J. (1979). The role of the sodium pump in the effects of potassium-depleted solutions on mammalian cardiac muscle. Journal of Physiology, 294, 279-301. . Publication link: b555f9fa-0d5b-40b6-b313-c4ea5f83e757
  • Eisner, D. A., Atwell, D., & Cohen, I. (1979). Voltage clamp and tracer flux data: effects of a restricted extracellular space. Quaterly Reviews of Biophysics, 12. . Publication link: de7abdcf-7272-423c-ab69-aca68128fec2
  • Eisner, D. A., Lederer, W. J., & Spindler, A. J. (1979). Thick slurry bevelling. A new technique for bevelling fine microelectrodes and micropipettes. Pflugers Archive, 381. . Publication link: 0f79f463-4788-4ef5-a2d1-e02ada118dc3

1978

  • Attwell, D., & Eisner, D. (1978). Discrete membrane surface charge distributions. Effect of fluctuations near individual channels. Biophysical Journal, 24(3), 869-875. . Publication link: 7d3be878-bfd0-484a-8fdd-81bc9a6cf6cb
  • Cohen, I., Eisner, D., & Noble, D. (1978). The action of adrenaline on pace-maker activity in cardiac Purkinje fibres. Journal of Physiology, 280, 155-168. . Publication link: 5d52b26a-2e5d-4a75-975c-fe9fd7812e91
  • Eisner, D. A., & Lederer, W. J. (1978). Characterization of the electrogenic sodium pump in cardiac Purkinje fibres. Journal of Physiology-London. . Publication link: d12fa434-f7b4-4dc0-8d79-03fdef0fc3c9