Miss Caroline Price

Institute Administrator and PA to Profesor Bernard Keavney

Publications

2013

  • Anand, S., Meyre, D., Pare, G., Bailey, S., Xie, C., Zhang, X., Montpetit, A., Desai, D., Bosch, J., Mohan, V., Diaz, R., McQueen, M., Cordell, H., Keavney, B., Yusuf, S., Gaudet, D., Gerstein, H., Engert, J. & . (2013). Genetic Information and the Prediction of Incident Type 2 Diabetes in a High-Risk Multi-Ethnic Population: The EpiDREAM Genetic Study. Diabetes Care, eScholarID:201249 | PMID:23603917 | DOI:10.2337/dc12-2553
  • Bates, M., Hollingsworth, K., Newman, J., Jakovljevic, D., Blamire, A., Macgowan, G., Keavney, B., Chinnery, P., Turnbull, D., Taylor, R., Trenell, M. & Gorman, G (2013). Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. Eur Heart J Cardiovasc Imaging, 14(7), 650-8. eScholarID:201228 | PMID:23129433 | DOI:10.1093/ehjci/jes226
  • Bates, M., Newman, J., Jakovljevic, D., Hollingsworth, K., Alston, C., Zalewski, P., Klawe, J., Blamire, A., Macgowan, G., Keavney, B., Bourke, J., Schaefer, A., McFarland, R., Newton, J., Turnbull, D., Taylor, R., Trenell, M. & Gorman, G (2013). Defining cardiac adaptations and safety of endurance training in patients with m.3243A>G-related mitochondrial disease. Int J Cardiol, eScholarID:201237 | PMID:23742928 | DOI:10.1016/j.ijcard.2013.05.062
  • Cordell, et al (2013). Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nat Genet, 45(7), 822-4. eScholarID:201257 | PMID:23708191 | DOI:10.1038/ng.2637
  • Cordell, H., Töpf, A., Mamasoula, C., Postma, A., Bentham, J., Zelenika, D., Heath, S., Blue, G., Cosgrove, C., Granados Riveron, J., Darlay, R., Soemedi, R., Wilson, I., Ayers, K., Rahman, T., Hall, D., Mulder, B., Zwinderman, A., van Engelen, K., Brook, J., Setchfield, K., Bu'Lock, F., Thornborough, C., O'Sullivan, J., Stuart, A., Parsons, J., Bhattacharya, S., Winlaw, D., Mital, S., Gewillig, M., Breckpot, J., Devriendt, K., Moorman, A., Rauch, A., Lathrop, G., Keavney, B. & Goodship, J (2013). Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Hum Mol Genet, 22(7), 1473-81. eScholarID:201245 | PMID:23297363 | DOI:10.1093/hmg/dds552
  • Harper, A., Mayosi, B., Rodriguez, A., Rahman, T., Hall, D., Mamasoula, C., Avery, P. & Keavney, B (2013). Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. PLoS One, 8(1), e55061. eScholarID:201229 | PMID:23372812 | DOI:10.1371/journal.pone.0055061
  • Lee, K., Santibanez-Koref, M., Polvikoski, T., Birchall, D., Mendelow, A. & Keavney, B (2013). Increased expression of fatty acid binding protein 4 and leptin in resident macrophages characterises atherosclerotic plaque rupture. Atherosclerosis, 226(1), 74-81. eScholarID:201252 | PMID:23122912 | DOI:10.1016/j.atherosclerosis.2012.09.037
  • Palomino Doza, J., Topf, A., Bentham, J., Bhattacharya, S., Cosgrove, C., Brook, D., Granados-Riveron, J., Bu Lock, F., O Sullivan, J., Stuart, A., Parsons, J., Relton, C., Goodship, J., Henderson, D. & Keavney, B (2013). Low-frequency intermediate penetrance variants in the ROCK1 gene predispose to Tetralogy of Fallot. BMC Genet, 14(1), 57. eScholarID:201238 | PMID:23782575 | DOI:10.1186/1471-2156-14-57
  • van Engelen, K., Postma, A., van de Meerakker, J., Roos-Hesselink, J., Helderman-van den Enden, A., Vliegen, H., Rahman, T., Baars, M., Sels, J., Bauer, U., Pickardt, T., Sperling, S., Moorman, A., Keavney, B., Goodship, J., Klaassen, S. & Mulder, B (2013). Ebstein's anomaly may be caused by mutations in the sarcomere protein gene MYH7. Neth Heart J, 21(3), 113-7. eScholarID:201235 | PMID:21604106 | DOI:10.1007/s12471-011-0141-1
  • Vermeer, A., VAN Engelen, K., Postma, A., Baars, M., Christiaans, I., DE Haij, S., Klaassen, S., Mulder, B. & Keavney, B (2013). Ebstein anomaly associated with left ventricular noncompaction: An autosomal dominant condition that can be caused by mutations in MYH7. Am J Med Genet C Semin Med Genet, eScholarID:201236 | PMID:23794396 | DOI:10.1002/ajmg.c.31365

2012

  • Chen, C., Bentham, J., Cosgrove, C., Braganca, J., Cuenda, A., Bamforth, S., Schneider, J., Watkins, H., Keavney, B., Davies, B. & Bhattacharya, S (2012). Functional significance of SRJ domain mutations in CITED2. PLoS One, 7(10), e46256. eScholarID:201248 | PMID:23082118 | DOI:10.1371/journal.pone.0046256
  • Goodship, J., Hall, D., Topf, A., Mamasoula, C., Griffin, H., Rahman, T., Glen, E., Tan, H., Palomino Doza, J., Relton, C., Bentham, J., Bhattacharya, S., Cosgrove, C., Brook, D., Granados-Riveron, J., Bu'Lock, F., O'Sullivan, J., Stuart, A., Parsons, J., Cordell, H. & Keavney, B (2012). A common variant in the PTPN11 gene contributes to the risk of tetralogy of Fallot. Circ Cardiovasc Genet, 5(3), 287-92. eScholarID:201221 | PMID:22503907 | DOI:10.1161/CIRCGENETICS.111.962035
  • Helgadottir, et al (2012). Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. J Am Coll Cardiol, 60(8), 722-9. eScholarID:201222 | PMID:22898070 | DOI:10.1016/j.jacc.2012.01.078
  • Hoffmann, J., Fiser, K., Weaver, J., Dimmick, I., Loeher, M., Pircher, H., Martin-Ruiz, C., Veerasamy, M., Keavney, B., von Zglinicki, T. & Spyridopoulos, I (2012). High-throughput 13-parameter immunophenotyping identifies shifts in the circulating T-cell compartment following reperfusion in patients with acute myocardial infarction. PLoS One, 7(10), e47155. eScholarID:201251 | PMID:23077561 | DOI:10.1371/journal.pone.0047155
  • Hollingsworth, K., Blamire, A., Keavney, B. & Macgowan, G (2012). Left ventricular torsion, energetics, and diastolic function in normal human aging. Am J Physiol Heart Circ Physiol, 302(4), H885-92. eScholarID:201254 | PMID:22180656 | DOI:10.1152/ajpheart.00985.2011
  • Horvath, R., Holinski-Feder, E., Neeve, V., Pyle, A., Griffin, H., Ashok, D., Foley, C., Hudson, G., Rautenstrauss, B., Nürnberg, G., Nürnberg, P., Kortler, J., Neitzel, B., Bässmann, I., Rahman, T., Keavney, B., Loughlin, J., Hambleton, S., Schoser, B., Lochmüller, H., Santibanez-Koref, M. & Chinnery, P (2012). A new phenotype of brain iron accumulation with dystonia, optic atrophy, and peripheral neuropathy. Mov Disord, 27(6), 789-93. eScholarID:201224 | PMID:22508347 | DOI:10.1002/mds.24980
  • Soemedi, R., Topf, A., Wilson, I., Darlay, R., Rahman, T., Glen, E., Hall, D., Huang, N., Bentham, J., Bhattacharya, S., Cosgrove, C., Brook, J., Granados-Riveron, J., Setchfield, K., Bu'lock, F., Thornborough, C., Devriendt, K., Breckpot, J., Hofbeck, M., Lathrop, M., Rauch, A., Blue, G., Winlaw, D., Hurles, M., Santibanez-Koref, M., Cordell, H., Goodship, J. & Keavney, B (2012). Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. Hum Mol Genet, 21(7), 1513-20. eScholarID:201242 | PMID:22199024 | DOI:10.1093/hmg/ddr589
  • Soemedi, R., Wilson, I., Bentham, J., Darlay, R., Töpf, A., Zelenika, D., Cosgrove, C., Setchfield, K., Thornborough, C., Granados-Riveron, J., Blue, G., Breckpot, J., Hellens, S., Zwolinkski, S., Glen, E., Mamasoula, C., Rahman, T., Hall, D., Rauch, A., Devriendt, K., Gewillig, M., O' Sullivan, J., Winlaw, D., Bu'Lock, F., Brook, J., Bhattacharya, S., Lathrop, M., Santibanez-Koref, M., Cordell, H., Goodship, J. & Keavney, B (2012). Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease. Am J Hum Genet, 91(3), 489-501. eScholarID:201232 | PMID:22939634 | DOI:10.1016/j.ajhg.2012.08.003
  • Tan, H., Glen, E., Töpf, A., Hall, D., O'Sullivan, J., Sneddon, L., Wren, C., Avery, P., Lewis, R., ten Dijke, P., Arthur, H., Goodship, J. & Keavney, B (2012). Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation. Hum Mutat, 33(4), 720-7. eScholarID:201255 | PMID:22275001 | DOI:10.1002/humu.22030
  • Twigg, S., Lloyd, D., Jenkins, D., Elçioglu, N., Cooper, C., Al-Sannaa, N., Annagür, A., Gillessen-Kaesbach, G., Hüning, I., Knight, S., Goodship, J., Keavney, B., Beales, P., Gileadi, O., McGowan, S. & Wilkie, A (2012). Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization. Am J Hum Genet, 91(5), 897-905. eScholarID:201240 | PMID:23063620 | DOI:10.1016/j.ajhg.2012.08.027
  • Yousaf, F., Collerton, J., Kingston, A., Kenny, A., Davies, K., Jagger, C., Robinson, L., Kirkwood, T. & Keavney, B (2012). Prevalence of left ventricular dysfunction in a UK community sample of very old people: the Newcastle 85+ study. Heart, 98(19), 1418-23. eScholarID:201243 | PMID:22859497 | DOI:10.1136/heartjnl-2012-302457

2011

  • Avery, P., Patel, S., Ibrahim, I., Walker, M. & Keavney, B (2011). Common variation in the adiponectin gene has an effect on systolic blood pressure. J Hum Hypertens, 25(12), 719-24. eScholarID:201231 | PMID:21248784 | DOI:10.1038/jhh.2010.122
  • Cunnington, M. & Keavney, B (2011). Genetic mechanisms mediating atherosclerosis susceptibility at the chromosome 9p21 locus. Curr Atheroscler Rep, 13(3), 193-201. eScholarID:201247 | PMID:21487702 | DOI:10.1007/s11883-011-0178-z
  • Dickinson, R., Griffin, H., Bigley, V., Reynard, L., Hussain, R., Haniffa, M., Lakey, J., Rahman, T., Wang, X., McGovern, N., Pagan, S., Cookson, S., McDonald, D., Chua, I., Wallis, J., Cant, A., Wright, M., Keavney, B., Chinnery, P., Loughlin, J., Hambleton, S., Santibanez-Koref, M. & Collin, M (2011). Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood, 118(10), 2656-8. eScholarID:201246 | PMID:21765025 | DOI:10.1182/blood-2011-06-360313
  • Hall, D., Mayosi, B., Rahman, T., Avery, P., Watkins, H. & Keavney, B (2011). Common variation in the CD36 (fatty acid translocase) gene is associated with left-ventricular mass. J Hypertens, 29(4), 690-5. eScholarID:201227 | PMID:21346626 | DOI:10.1097/HJH.0b013e3283440115
  • Martin-Ruiz, C., Jagger, C., Kingston, A., Collerton, J., Catt, M., Davies, K., Dunn, M., Hilkens, C., Keavney, B., Pearce, S., den Elzen, W., Talbot, D., Wiley, L., Bond, J., Mathers, J., Eccles, M., Robinson, L., James, O., Kirkwood, T. & von Zglinicki, T (2011). Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study. Mech Ageing Dev, 132(10), 496-502. eScholarID:201226 | PMID:21864562 | DOI:10.1016/j.mad.2011.08.001
  • Postma, A., van Engelen, K., van de Meerakker, J., Rahman, T., Probst, S., Baars, M., Bauer, U., Pickardt, T., Sperling, S., Berger, F., Moorman, A., Mulder, B., Thierfelder, L., Keavney, B., Goodship, J. & Klaassen, S (2011). Mutations in the sarcomere gene MYH7 in Ebstein anomaly. Circ Cardiovasc Genet, 4(1), 43-50. eScholarID:201241 | PMID:21127202 | DOI:10.1161/CIRCGENETICS.110.957985
  • Rahman, T., Mayosi, B., Hall, D., Avery, P., Stewart, P., Connell, J., Watkins, H. & Keavney, B (2011). Common variation at the 11-β hydroxysteroid dehydrogenase type 1 gene is associated with left ventricular mass. Circ Cardiovasc Genet, 4(2), 156-62. eScholarID:201244 | PMID:21402901 | DOI:10.1161/CIRCGENETICS.110.958496
  • Rahman, T., Walker, E., Mayosi, B., Hall, D., Avery, P., Connell, J., Watkins, H., Stewart, P. & Keavney, B (2011). Genotype at the P554L variant of the hexose-6 phosphate dehydrogenase gene is associated with carotid intima-medial thickness. PLoS One, 6(8), e23248. eScholarID:201250 | PMID:21858044 | DOI:10.1371/journal.pone.0023248
  • Siddle, K., Goodship, J., Keavney, B. & Santibanez-Koref, M (2011). Bases adjacent to mononucleotide repeats show an increased single nucleotide polymorphism frequency in the human genome. Bioinformatics, 27(7), 895-8. eScholarID:201223 | PMID:21317137 | DOI:10.1093/bioinformatics/btr067

2010

  • Bailey, S., Xie, C., Do, R., Montpetit, A., Diaz, R., Mohan, V., Keavney, B., Yusuf, S., Gerstein, H., Engert, J., Anand, S. & . (2010). Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Diabetes Care, 33(10), 2250-3. eScholarID:201256 | PMID:20628086 | DOI:10.2337/dc10-0452
  • Cunnington, M., Santibanez Koref, M., Mayosi, B., Burn, J. & Keavney, B (2010). Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. PLoS Genet, 6(4), e1000899. eScholarID:201230 | PMID:20386740 | DOI:10.1371/journal.pgen.1000899
  • Griffin, H., Töpf, A., Glen, E., Zweier, C., Stuart, A., Parsons, J., Peart, I., Deanfield, J., O'Sullivan, J., Rauch, A., Scambler, P., Burn, J., Cordell, H., Keavney, B. & Goodship, J (2010). Systematic survey of variants in TBX1 in non-syndromic tetralogy of Fallot identifies a novel 57 base pair deletion that reduces transcriptional activity but finds no evidence for association with common variants. Heart, 96(20), 1651-5. eScholarID:201239 | PMID:20937753 | DOI:10.1136/hrt.2010.200121
  • Keavney, B (2010). The interleukin-1 cluster, dyslipidaemia and risk of myocardial infarction. BMC Med, 8, 6. eScholarID:201253 | PMID:20070881 | DOI:10.1186/1741-7015-8-6
  • Kiechl, S., Laxton, R., Xiao, Q., Hernesniemi, J., Raitakari, O., Kähönen, M., Mayosi, B., Jula, A., Moilanen, L., Willeit, J., Watkins, H., Samani, N., Lehtimäki, T., Keavney, B., Xu, Q. & Ye, S (2010). Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis. Arterioscler Thromb Vasc Biol, 30(12), 2678-83. eScholarID:201233 | PMID:20847302 | DOI:10.1161/ATVBAHA.110.213785
  • Lang, C., Gupta, S., Kalra, P., Keavney, B., Menown, I., Morley, C. & Padmanabhan, S (2010). Elevated heart rate and cardiovascular outcomes in patients with coronary artery disease: clinical evidence and pathophysiological mechanisms. Atherosclerosis, 212(1), 1-8. eScholarID:201234 | PMID:20152981 | DOI:10.1016/j.atherosclerosis.2010.01.029
  • van Engelen, K., Topf, A., Keavney, B., Goodship, J., van der Velde, E., Baars, M., Snijder, S., Moorman, A., Postma, A. & Mulder, B (2010). 22q11.2 Deletion Syndrome is under-recognised in adult patients with tetralogy of Fallot and pulmonary atresia. Heart, 96(8), 621-4. eScholarID:201225 | PMID:20357389 | DOI:10.1136/hrt.2009.182642

2009

  • Alvarez-Madrazo, S., Padmanabhan, S., Mayosi, B., Watkins, H., Avery, P., Wallace, A., Fraser, R., Davies, E., Keavney, B. & Connell, J (2009). Familial and phenotypic associations of the aldosterone Renin ratio. J Clin Endocrinol Metab, 94(11), 4324-33. eScholarID:201262 | PMID:19820005 | DOI:10.1210/jc.2009-1406
  • Anand, S., Xie, C., Paré, G., Montpetit, A., Rangarajan, S., McQueen, M., Cordell, H., Keavney, B., Yusuf, S., Hudson, T., Engert, J. & . (2009). Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study. Circ Cardiovasc Genet, 2(1), 16-25. eScholarID:201268 | PMID:20031563 | DOI:10.1161/CIRCGENETICS.108.813709
  • Cunnington, M., Kay, C., Avery, P., Mayosi, B., Koref, M. & Keavney, B (2009). STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression. BMC Med Genet, 10, 135. eScholarID:201272 | PMID:20003416 | DOI:10.1186/1471-2350-10-135
  • Griffin, H., Hall, D., Topf, A., Eden, J., Stuart, A., Parsons, J., Peart, I., Deanfield, J., O'Sullivan, J., Babu-Narayan, S., Gatzoulis, M., Bu'lock, F., Bhattacharya, S., Bentham, J., Farrall, M., Granados Riveron, J., Brook, J., Burn, J., Cordell, H., Goodship, J. & Keavney, B (2009). Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation. PLoS One, 4(3), e4978. eScholarID:201270 | PMID:19308252 | DOI:10.1371/journal.pone.0004978
  • Leong, F., Freeman, L. & Keavney, B (2009). Fresh fields and pathways new: recent genetic insights into cardiac malformation. Heart, 95(6), 442-7. eScholarID:201275 | PMID:19252006 | DOI:10.1136/hrt.2006.105130
  • Thomas, H., Avery, P., Ahmed, J., Edwards, R., Purcell, I., Zaman, A., Arthur, H. & Keavney, B (2009). Local vessel injury following percutaneous coronary intervention does not promote early mobilisation of endothelial progenitor cells in the absence of myocardial necrosis. Heart, 95(7), 555-8. eScholarID:201273 | PMID:18977801 | DOI:10.1136/hrt.2008.146662
  • Thomas, H., Parry, G., Dark, J., Arthur, H. & Keavney, B (2009). Circulating endothelial progenitor cell numbers are not associated with donor organ age or allograft vasculopathy in cardiac transplant recipients. Atherosclerosis, 202(2), 612-6. eScholarID:201265 | PMID:18589426 | DOI:10.1016/j.atherosclerosis.2008.05.020

2008

  • Gaukrodger, N., Avery, P. & Keavney, B (2008). Plasma potassium level is associated with common genetic variation in the beta-subunit of the epithelial sodium channel. Am J Physiol Regul Integr Comp Physiol, 294(3), R1068-72. eScholarID:201271 | PMID:18184758 | DOI:10.1152/ajpregu.00732.2007
  • Keavney, B (2008). More evidence against a causal association between C-reactive protein and diabetes. PLoS Med, 5(8), e174. eScholarID:201274 | PMID:18700815 | DOI:10.1371/journal.pmed.0050174
  • Mayosi, B., Avery, P., Farrall, M., Keavney, B. & Watkins, H (2008). Genome-wide linkage analysis of electrocardiographic and echocardiographic left ventricular hypertrophy in families with hypertension. Eur Heart J, 29(4), 525-30. eScholarID:201269 | PMID:18276622 | DOI:10.1093/eurheartj/ehn028
  • Palomino-Doza, J., Rahman, T., Avery, P., Mayosi, B., Farrall, M., Watkins, H., Edwards, C. & Keavney, B (2008). Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. Hypertension, 52(5), 980-5. eScholarID:201263 | PMID:18852390 | DOI:10.1161/HYPERTENSIONAHA.108.113282
  • Rahman, T., Baker, M., Hall, D., Avery, P. & Keavney, B (2008). Common genetic variation in the type A endothelin-1 receptor is associated with ambulatory blood pressure: a family study. J Hum Hypertens, 22(4), 282-8. eScholarID:201266 | PMID:18172451 | DOI:10.1038/sj.jhh.1002322
  • Serre, D., Montpetit, A., Paré, G., Engert, J., Yusuf, S., Keavney, B., Hudson, T. & Anand, S (2008). Correction of population stratification in large multi-ethnic association studies. PLoS One, 3(1), e1382. eScholarID:201267 | PMID:18196181 | DOI:10.1371/journal.pone.0001382
  • Thompson, A., Di Angelantonio, E., Sarwar, N., Erqou, S., Saleheen, D., Dullaart, R., Keavney, B., Ye, Z. & Danesh, J (2008). Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA, 299(23), 2777-88. eScholarID:201264 | PMID:18560005 | DOI:10.1001/jama.299.23.2777
  • Thompson, A., Di Angelantonio, E., Sarwar, N., Erqou, S., Saleheen, D., Dullaart, R., Keavney, B., Ye, Z. & Danesh, J (2008). Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA, 299(23), 2777-88. eScholarID:201381 | PMID:18560005 | DOI:10.1001/jama.299.23.2777